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Athar H. Chishti

TitleProfessor
InstitutionTufts University School of Medicine
DepartmentDevelopmental, Molecular and Chemical Biology
AddressDevelopmental, Molecular and Chemical Biology
Tufts University School of Medicine
136 Harrison Avenue, Jaharis Room 714
Boston MA 02111
Phone(617) 636-3457
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Schiemer J, Bohm A, Lin L, Merrill-Skoloff G, Flaumenhaft R, Huang JS, Le Breton GC, Chishti AH. Galpha13 Switch Region 2 Relieves Talin Autoinhibition to activate alphaIIbbeta3 Integrin. J Biol Chem. 2016 Nov 1. PMID: 27803165.
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    2. Ranjan R, Karpurapu M, Rani A, Chishti AH, Christman JW. Hemozoin Regulates iNOS Expression by Modulating the Transcription Factor NF-?B in Macrophages. Biochem Mol Biol J. 2016; 2(2). PMID: 27790644.
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    3. Nwankwo JO, Lei J, Xu J, Rivera A, Gupta K, Chishti AH. Genetic inactivation of calpain-1 attenuates pain sensitivity in a humanized mouse model of sickle cell disease. Haematologica. 2016 Oct; 101(10):e397-e400. PMID: 27418647.
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    4. Lu Y, Hanada T, Fujiwara Y, Nwankwo JO, Wieschhaus AJ, Hartwig J, Huang S, Han J, Chishti AH. Gene disruption of dematin causes precipitous loss of erythrocyte membrane stability and severe hemolytic anemia. Blood. 2016 Jul 7; 128(1):93-103. PMID: 27073223.
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    5. Howatt DA, Balakrishnan A, Moorleghen JJ, Muniappan L, Rateri DL, Uchida HA, Takano J, Saido TC, Chishti AH, Baud L, Subramanian V. Leukocyte Calpain Deficiency Reduces Angiotensin II-Induced Inflammation and Atherosclerosis But Not Abdominal Aortic Aneurysms in Mice. Arterioscler Thromb Vasc Biol. 2016 May; 36(5):835-45. PMID: 26966280.
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    6. Srinivasan S, Schiemer J, Zhang X, Chishti AH, Le Breton GC. Ga13 Switch Region 2 Binds to the Talin Head Domain and Activates aIIbß3 Integrin in Human Platelets. J Biol Chem. 2015 Oct 9; 290(41):25129-39. PMID: 26292217.
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    7. Baldwin MR, Li X, Hanada T, Liu SC, Chishti AH. Merozoite surface protein 1 recognition of host glycophorin A mediates malaria parasite invasion of red blood cells. Blood. 2015 Apr 23; 125(17):2704-11. PMID: 25778531.
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    8. Chishti AH. Malaria selectively targets pregnancy receptors. Blood. 2015 Jan 8; 125(2):217-8. PMID: 25573970.
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    9. Baldwin M, Yamodo I, Ranjan R, Li X, Mines G, Marinkovic M, Hanada T, Oh SS, Chishti AH. Human erythrocyte band 3 functions as a receptor for the sialic acid-independent invasion of Plasmodium falciparum. Role of the RhopH3-MSP1 complex. Biochim Biophys Acta. 2014 Dec; 1843(12):2855-70. PMID: 25157665; NIHMSID: NIHMS624733 [Available on 12/01/15].
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    10. Baldwin M, Russo C, Li X, Chishti AH. Plasmodium falciparum signal peptide peptidase cleaves malaria heat shock protein 101 (HSP101). Implications for gametocytogenesis. Biochem Biophys Res Commun. 2014 Aug 8; 450(4):1427-32. PMID: 25017910; NIHMSID: NIHMS613002 [Available on 08/08/15].
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    11. Wu Z, Chen X, Liu F, Chen W, Wu P, Wieschhaus AJ, Chishti AH, Roche PA, Chen WM, Lin TJ. Calpain-1 contributes to IgE-mediated mast cell activation. J Immunol. 2014 Jun 1; 192(11):5130-9. PMID: 24760147; NIHMSID: NIHMS580859 [Available on 06/01/15].
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    12. Wang Y, Briz V, Chishti A, Bi X, Baudry M. Distinct roles for µ-calpain and m-calpain in synaptic NMDAR-mediated neuroprotection and extrasynaptic NMDAR-mediated neurodegeneration. J Neurosci. 2013 Nov 27; 33(48):18880-92. PMID: 24285894; PMCID: PMC3841454.
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    13. Subramanian V, Moorleghen JJ, Balakrishnan A, Howatt DA, Chishti AH, Uchida HA. Calpain-2 compensation promotes angiotensin II-induced ascending and abdominal aortic aneurysms in calpain-1 deficient mice. PLoS One. 2013; 8(8):e72214. PMID: 23977256; PMCID: PMC3747148.
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    14. Kemp CM, Oliver WT, Wheeler TL, Chishti AH, Koohmaraie M. The effects of Capn1 gene inactivation on skeletal muscle growth, development, and atrophy, and the compensatory role of other proteolytic systems. J Anim Sci. 2013 Jul; 91(7):3155-67. PMID: 23798514; NIHMSID: NIHMS563023.
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    15. Mattheij NJ, Gilio K, van Kruchten R, Jobe SM, Wieschhaus AJ, Chishti AH, Collins P, Heemskerk JW, Cosemans JM. Dual mechanism of integrin aIIbß3 closure in procoagulant platelets. J Biol Chem. 2013 May 10; 288(19):13325-36. PMID: 23519467; PMCID: PMC3650371.
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    16. Wieschhaus A, Khan A, Zaidi A, Rogalin H, Hanada T, Liu F, De Franceschi L, Brugnara C, Rivera A, Chishti AH. Calpain-1 knockout reveals broad effects on erythrocyte deformability and physiology. Biochem J. 2012 Nov 15; 448(1):141-52. PMID: 22870887; NIHMSID: NIHMS558249.
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    17. De Franceschi L, Franco RS, Bertoldi M, Brugnara C, Matté A, Siciliano A, Wieschhaus AJ, Chishti AH, Joiner CH. Pharmacological inhibition of calpain-1 prevents red cell dehydration and reduces Gardos channel activity in a mouse model of sickle cell disease. FASEB J. 2013 Feb; 27(2):750-9. PMID: 23085996; PMCID: PMC3545531.
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    18. Wieschhaus AJ, Le Breton GC, Chishti AH. Headpiece domain of dematin regulates calcium mobilization and signaling in platelets. J Biol Chem. 2012 Nov 30; 287(49):41218-31. PMID: 23060452; PMCID: PMC3510821.
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    19. Kuchay SM, Wieschhaus AJ, Marinkovic M, Herman IM, Chishti AH. Targeted gene inactivation reveals a functional role of calpain-1 in platelet spreading. J Thromb Haemost. 2012 Jun; 10(6):1120-32. PMID: 22458296; NIHMSID: NIHMS558257.
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    20. Yamada KH, Kozlowski DA, Seidl SE, Lance S, Wieschhaus AJ, Sundivakkam P, Tiruppathi C, Chishti I, Herman IM, Kuchay SM, Chishti AH. Targeted gene inactivation of calpain-1 suppresses cortical degeneration due to traumatic brain injury and neuronal apoptosis induced by oxidative stress. J Biol Chem. 2012 Apr 13; 287(16):13182-93. PMID: 22367208; PMCID: PMC3339949.
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    21. Li X, Marinkovic M, Russo C, McKnight CJ, Coetzer TL, Chishti AH. Identification of a specific region of Plasmodium falciparum EBL-1 that binds to host receptor glycophorin B and inhibits merozoite invasion in human red blood cells. Mol Biochem Parasitol. 2012 May; 183(1):23-31. PMID: 22273481; NIHMSID: NIHMS350556.
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    22. Takano J, Mihira N, Fujioka R, Hosoki E, Chishti AH, Saido TC. Vital role of the calpain-calpastatin system for placental-integrity-dependent embryonic survival. Mol Cell Biol. 2011 Oct; 31(19):4097-106. PMID: 21791606; PMCID: PMC3187362.
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    23. Liu F, Khan AA, Chishti AH, Ostafin AE. Atomic force microscopy demonstration of cytoskeleton instability in mouse erythrocytes with dematin-headpiece and ß-adducin deficiency. Scanning. 2011 Nov-Dec; 33(6):426-36. PMID: 21638291; NIHMSID: NIHMS300029.
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    24. Lorand L, Murthy SN, Khan AA, Xue W, Lockridge O, Chishti AH. Transglutaminase-mediated remodeling of the human erythrocyte membrane skeleton: relevance for erythrocyte diseases with shortened cell lifespan. Adv Enzymol Relat Areas Mol Biol. 2011; 78:385-414. PMID: 22220479; NIHMSID: NIHMS363261.
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    25. Huckaba TM, Gennerich A, Wilhelm JE, Chishti AH, Vale RD. Kinesin-73 is a processive motor that localizes to Rab5-containing organelles. J Biol Chem. 2011 Mar 4; 286(9):7457-67. PMID: 21169635; PMCID: PMC3045001.
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    26. Tsurudome K, Tsang K, Liao EH, Ball R, Penney J, Yang JS, Elazzouzi F, He T, Chishti A, Lnenicka G, Lai EC, Haghighi AP. The Drosophila miR-310 cluster negatively regulates synaptic strength at the neuromuscular junction. Neuron. 2010 Dec 9; 68(5):879-93. PMID: 21145002; NIHMSID: NIHMS253481.
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    27. Tong Y, Tempel W, Wang H, Yamada K, Shen L, Senisterra GA, MacKenzie F, Chishti AH, Park HW. Phosphorylation-independent dual-site binding of the FHA domain of KIF13 mediates phosphoinositide transport via centaurin alpha1. Proc Natl Acad Sci U S A. 2010 Nov 23; 107(47):20346-51. PMID: 21057110; PMCID: PMC2996657.
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    28. Kang MY, Zhang Y, Matkovich SJ, Diwan A, Chishti AH, Dorn GW. Receptor-independent cardiac protein kinase Calpha activation by calpain-mediated truncation of regulatory domains. Circ Res. 2010 Oct 1; 107(7):903-12. PMID: 20689063; NIHMSID: NIHMS229481.
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    29. Quinn BJ, Welch EJ, Kim AC, Lokuta MA, Huttenlocher A, Khan AA, Kuchay SM, Chishti AH. Erythrocyte scaffolding protein p55/MPP1 functions as an essential regulator of neutrophil polarity. Proc Natl Acad Sci U S A. 2009 Nov 24; 106(47):19842-7. PMID: 19897731; PMCID: PMC2785254.
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    30. Bolis A, Coviello S, Visigalli I, Taveggia C, Bachi A, Chishti AH, Hanada T, Quattrini A, Previtali SC, Biffi A, Bolino A. Dlg1, Sec8, and Mtmr2 regulate membrane homeostasis in Schwann cell myelination. J Neurosci. 2009 Jul 8; 29(27):8858-70. PMID: 19587293.
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    31. Mohseni M, Chishti AH. Regulatory models of RhoA suppression by dematin, a cytoskeletal adaptor protein. Cell Adh Migr. 2009 Apr-Jun; 3(2):191-4. PMID: 19262171; PMCID: PMC2679884.
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    32. Mays TA, Sanford JL, Hanada T, Chishti AH, Rafael-Fortney JA. Glutamate receptors localize postsynaptically at neuromuscular junctions in mice. Muscle Nerve. 2009 Mar; 39(3):343-9. PMID: 19208409; NIHMSID: NIHMS563006.
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    33. Chen L, Jiang ZG, Khan AA, Chishti AH, McKnight CJ. Dematin exhibits a natively unfolded core domain and an independently folded headpiece domain. Protein Sci. 2009 Mar; 18(3):629-36. PMID: 19241372; PMCID: PMC2760368.
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    34. Li X, Chen H, Bahamontes-Rosa N, Kun JF, Traore B, Crompton PD, Chishti AH. Plasmodium falciparum signal peptide peptidase is a promising drug target against blood stage malaria. Biochem Biophys Res Commun. 2009 Mar 13; 380(3):454-9. PMID: 19174148; NIHMSID: NIHMS563009.
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    35. Seo PS, Quinn BJ, Khan AA, Zeng L, Takoudis CG, Hanada T, Bolis A, Bolino A, Chishti AH. Identification of erythrocyte p55/MPP1 as a binding partner of NF2 tumor suppressor protein/Merlin. Exp Biol Med (Maywood). 2009 Mar; 234(3):255-62. PMID: 19144871; NIHMSID: NIHMS563000.
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    36. Seo PS, Jeong JJ, Zeng L, Takoudis CG, Quinn BJ, Khan AA, Hanada T, Chishti AH. Alternatively spliced exon 5 of the FERM domain of protein 4.1R encodes a novel binding site for erythrocyte p55 and is critical for membrane targeting in epithelial cells. Biochim Biophys Acta. 2009 Feb; 1793(2):281-9. PMID: 18952129; NIHMSID: NIHMS93542.
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    37. Li X, Chen H, Khan AA, Lauterbach SB, Lanzillotti R, Rai PR, Kane RS, Coetzer TL, Chishti AH. Receptor-based identification of an inhibitory peptide against blood stage malaria. Biochem Biophys Res Commun. 2008 Nov 21; 376(3):489-93. PMID: 18793615; NIHMSID: NIHMS74880.
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    38. Unno K, Hanada T, Chishti AH. Functional involvement of human discs large tumor suppressor in cytokinesis. Exp Cell Res. 2008 Oct 15; 314(17):3118-29. PMID: 18760273; NIHMSID: NIHMS76304.
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    39. Mohseni M, Chishti AH. The headpiece domain of dematin regulates cell shape, motility, and wound healing by modulating RhoA activation. Mol Cell Biol. 2008 Aug; 28(15):4712-8. PMID: 18505823; PMCID: PMC2493358.
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    40. Mohseni M, Chishti AH. Erythrocyte dematin is a candidate gene for Marie Unna hereditary hypotrichosis and related hairloss disorders. Am J Hematol. 2008 May; 83(5):430-2. PMID: 18273904.
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    41. Khan AA, Hanada T, Mohseni M, Jeong JJ, Zeng L, Gaetani M, Li D, Reed BC, Speicher DW, Chishti AH. Dematin and adducin provide a novel link between the spectrin cytoskeleton and human erythrocyte membrane by directly interacting with glucose transporter-1. J Biol Chem. 2008 May 23; 283(21):14600-9. PMID: 18347014; PMCID: PMC2386908.
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    42. Sha D, Jin Y, Wu H, Wei J, Lin CH, Lee YH, Buddhala C, Kuchay S, Chishti AH, Wu JY. Role of mu-calpain in proteolytic cleavage of brain L-glutamic acid decarboxylase. Brain Res. 2008 May 1; 1207:9-18. PMID: 18377878; NIHMSID: NIHMS47969.
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    43. Li X, Chen H, Oh SS, Chishti AH. A Presenilin-like protease associated with Plasmodium falciparum micronemes is involved in erythrocyte invasion. Mol Biochem Parasitol. 2008 Mar; 158(1):22-31. PMID: 18160114; NIHMSID: NIHMS40595.
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    44. Flevaris P, Stojanovic A, Gong H, Chishti A, Welch E, Du X. A molecular switch that controls cell spreading and retraction. J Cell Biol. 2007 Nov 5; 179(3):553-65. PMID: 17967945; PMCID: PMC2064799.
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    45. Yamada KH, Hanada T, Chishti AH. The effector domain of human Dlg tumor suppressor acts as a switch that relieves autoinhibition of kinesin-3 motor GAKIN/KIF13B. Biochemistry. 2007 Sep 4; 46(35):10039-45. PMID: 17696365; NIHMSID: NIHMS62634.
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    46. Sarang Z, Mádi A, Koy C, Varga S, Glocker MO, Ucker DS, Kuchay S, Chishti AH, Melino G, Fésüs L, Szondy Z. Tissue transglutaminase (TG2) facilitates phosphatidylserine exposure and calpain activity in calcium-induced death of erythrocytes. Cell Death Differ. 2007 Oct; 14(10):1842-4. PMID: 17612588; NIHMSID: NIHMS562993.
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    47. Yamada KH, Hanada T, Chishti AH. [Transport of PIP3 mediated by kinesin regulates neuronal cell polarity]. Tanpakushitsu Kakusan Koso. 2007 Jul; 52(8):893-9. PMID: 17642273.
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    48. Kuchay SM, Kim N, Grunz EA, Fay WP, Chishti AH. Double knockouts reveal that protein tyrosine phosphatase 1B is a physiological target of calpain-1 in platelets. Mol Cell Biol. 2007 Sep; 27(17):6038-52. PMID: 17576811; PMCID: PMC1952154.
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    49. Li X, Chen H, Jeong JJ, Chishti AH. BDA-410: a novel synthetic calpain inhibitor active against blood stage malaria. Mol Biochem Parasitol. 2007 Sep; 155(1):26-32. PMID: 17583361; NIHMSID: NIHMS27997.
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    50. Kuchay SM, Chishti AH. Calpain-mediated regulation of platelet signaling pathways. Curr Opin Hematol. 2007 May; 14(3):249-54. PMID: 17414215; NIHMSID: NIHMS562995.
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    51. Chen H, Khan AA, Liu F, Gilligan DM, Peters LL, Messick J, Haschek-Hock WM, Li X, Ostafin AE, Chishti AH. Combined deletion of mouse dematin-headpiece and beta-adducin exerts a novel effect on the spectrin-actin junctions leading to erythrocyte fragility and hemolytic anemia. J Biol Chem. 2007 Feb 9; 282(6):4124-35. PMID: 17142833.
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    52. Jindal HK, Yoshinaga K, Seo PS, Lutchman M, Dion PA, Rouleau GA, Hanada T, Chishti AH. Purification of the NF2 tumor suppressor protein from human erythrocytes. Can J Neurol Sci. 2006 Nov; 33(4):394-402. PMID: 17168165.
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    53. Geesink GH, Kuchay S, Chishti AH, Koohmaraie M. Micro-calpain is essential for postmortem proteolysis of muscle proteins. J Anim Sci. 2006 Oct; 84(10):2834-40. PMID: 16971586.
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    54. Xi X, Flevaris P, Stojanovic A, Chishti A, Phillips DR, Lam SC, Du X. Tyrosine phosphorylation of the integrin beta 3 subunit regulates beta 3 cleavage by calpain. J Biol Chem. 2006 Oct 6; 281(40):29426-30. PMID: 16935858.
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    55. Horiguchi K, Hanada T, Fukui Y, Chishti AH. Transport of PIP3 by GAKIN, a kinesin-3 family protein, regulates neuronal cell polarity. J Cell Biol. 2006 Jul 31; 174(3):425-36. PMID: 16864656; PMCID: PMC2064238.
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    56. Micale N, Kozikowski AP, Ettari R, Grasso S, Zappalà M, Jeong JJ, Kumar A, Hanspal M, Chishti AH. Novel peptidomimetic cysteine protease inhibitors as potential antimalarial agents. J Med Chem. 2006 Jun 1; 49(11):3064-7. PMID: 16722625.
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    57. Jeong JJ, Kumar A, Hanada T, Seo PS, Li X, Hanspal M, Chishti AH. Cloning and characterization of Plasmodium falciparum cysteine protease, falcipain-2B. Blood Cells Mol Dis. 2006 May-Jun; 36(3):429-35. PMID: 16595182.
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    58. Marzia M, Chiusaroli R, Neff L, Kim NY, Chishti AH, Baron R, Horne WC. Calpain is required for normal osteoclast function and is down-regulated by calcitonin. J Biol Chem. 2006 Apr 7; 281(14):9745-54. PMID: 16461769; NIHMSID: NIHMS11561.
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    59. Kariuki MM, Li X, Yamodo I, Chishti AH, Oh SS. Two Plasmodium falciparum merozoite proteins binding to erythrocyte band 3 form a direct complex. Biochem Biophys Res Commun. 2005 Dec 30; 338(4):1690-5. PMID: 16289042.
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    60. Grammer M, Kuchay S, Chishti A, Baudry M. Lack of phenotype for LTP and fear conditioning learning in calpain 1 knock-out mice. Neurobiol Learn Mem. 2005 Nov; 84(3):222-7. PMID: 16150618.
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    61. Soni S, Dhawan S, Rosen KM, Chafel M, Chishti AH, Hanspal M. Characterization of events preceding the release of malaria parasite from the host red blood cell. Blood Cells Mol Dis. 2005 Sep-Oct; 35(2):201-11. PMID: 16087367.
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    62. Venkateswarlu K, Hanada T, Chishti AH. Centaurin-alpha1 interacts directly with kinesin motor protein KIF13B. J Cell Sci. 2005 Jun 1; 118(Pt 11):2471-84. PMID: 15923660.
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    63. Du M, Fan X, Hanada T, Gao H, Lutchman M, Brandsma JL, Chishti AH, Chen JJ. Association of cottontail rabbit papillomavirus E6 oncoproteins with the hDlg/SAP97 tumor suppressor. J Cell Biochem. 2005 Apr 1; 94(5):1038-45. PMID: 15669058.
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    64. Oh SS, Chishti AH. Host receptors in malaria merozoite invasion. Curr Top Microbiol Immunol. 2005; 295:203-32. PMID: 16265892.
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    65. Blot V, Delamarre L, Perugi F, Pham D, Bénichou S, Benarous R, Hanada T, Chishti AH, Dokhélar MC, Pique C. Human Dlg protein binds to the envelope glycoproteins of human T-cell leukemia virus type 1 and regulates envelope mediated cell-cell fusion in T lymphocytes. J Cell Sci. 2004 Aug 1; 117(Pt 17):3983-93. PMID: 15286176.
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    66. Lin HT, Steller MA, Aish L, Hanada T, Chishti AH. Differential expression of human Dlg in cervical intraepithelial neoplasias. Gynecol Oncol. 2004 May; 93(2):422-8. PMID: 15099956.
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    67. Frank BS, Vardar D, Chishti AH, McKnight CJ. The NMR structure of dematin headpiece reveals a dynamic loop that is conformationally altered upon phosphorylation at a distal site. J Biol Chem. 2004 Feb 27; 279(9):7909-16. PMID: 14660664.
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    68. Li X, Chen H, Oo TH, Daly TM, Bergman LW, Liu SC, Chishti AH, Oh SS. A co-ligand complex anchors Plasmodium falciparum merozoites to the erythrocyte invasion receptor band 3. J Biol Chem. 2004 Feb 13; 279(7):5765-71. PMID: 14630931.
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    69. O'Neill GM, Prasanna Murthy SN, Lorand L, Khanna R, Liu SC, Hanspal M, Hanada T, Chishti AH. Activation of transglutaminase in mu-calpain null erythrocytes. Biochem Biophys Res Commun. 2003 Jul 25; 307(2):327-31. PMID: 12859959.
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    70. Hanada T, Takeuchi A, Sondarva G, Chishti AH. Protein 4.1-mediated membrane targeting of human discs large in epithelial cells. J Biol Chem. 2003 Sep 5; 278(36):34445-50. PMID: 12807908.
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    71. Dhawan S, Dua M, Chishti AH, Hanspal M. Ankyrin peptide blocks falcipain-2-mediated malaria parasite release from red blood cells. J Biol Chem. 2003 Aug 8; 278(32):30180-6. PMID: 12775709.
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    72. Goel VK, Li X, Chen H, Liu SC, Chishti AH, Oh SS. Band 3 is a host receptor binding merozoite surface protein 1 during the Plasmodium falciparum invasion of erythrocytes. Proc Natl Acad Sci U S A. 2003 Apr 29; 100(9):5164-9. PMID: 12692305; PMCID: PMC154316.
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    73. Asaba N, Hanada T, Takeuchi A, Chishti AH. Direct interaction with a kinesin-related motor mediates transport of mammalian discs large tumor suppressor homologue in epithelial cells. J Biol Chem. 2003 Mar 7; 278(10):8395-400. PMID: 12496241.
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    74. Hanspal M, Dua M, Takakuwa Y, Chishti AH, Mizuno A. Plasmodium falciparum cysteine protease falcipain-2 cleaves erythrocyte membrane skeletal proteins at late stages of parasite development. Blood. 2002 Aug 1; 100(3):1048-54. PMID: 12130521.
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    75. Hanspal M, Goel VK, Oh SS, Chishti AH. Erythrocyte calpain is dispensable for malaria parasite invasion and growth. Mol Biochem Parasitol. 2002 Jul; 122(2):227-9. PMID: 12106878.
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    76. Khanna R, Chang SH, Andrabi S, Azam M, Kim A, Rivera A, Brugnara C, Low PS, Liu SC, Chishti AH. Headpiece domain of dematin is required for the stability of the erythrocyte membrane. Proc Natl Acad Sci U S A. 2002 May 14; 99(10):6637-42. PMID: 12011427; PMCID: PMC124455.
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    77. Vardar D, Chishti AH, Frank BS, Luna EJ, Noegel AA, Oh SW, Schleicher M, McKnight CJ. Villin-type headpiece domains show a wide range of F-actin-binding affinities. Cell Motil Cytoskeleton. 2002 May; 52(1):9-21. PMID: 11977079.
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    78. Lutchman M, Kim AC, Cheng L, Whitehead IP, Oh SS, Hanspal M, Boukharov AA, Hanada T, Chishti AH. Dematin interacts with the Ras-guanine nucleotide exchange factor Ras-GRF2 and modulates mitogen-activated protein kinase pathways. Eur J Biochem. 2002 Jan; 269(2):638-49. PMID: 11856323.
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    79. Huang S, Lichtenauer UD, Pack S, Wang C, Kim AC, Lutchman M, Koch CA, Torres-Cruz J, Huang SC, Benz EJ, Christiansen H, Dockhorn-Dworniczak B, Poremba C, Vortmeyer AO, Chishti AH, Zhuang Z. Reassignment of the EPB4.1 gene to 1p36 and assessment of its involvement in neuroblastomas. Eur J Clin Invest. 2001 Oct; 31(10):907-14. PMID: 11737230.
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    80. Jannatipour M, Dion P, Khan S, Jindal H, Fan X, Laganière J, Chishti AH, Rouleau GA. Schwannomin isoform-1 interacts with syntenin via PDZ domains. J Biol Chem. 2001 Aug 31; 276(35):33093-100. PMID: 11432873.
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    81. Tseng TC, Marfatia SM, Bryant PJ, Pack S, Zhuang Z, O'Brien JE, Lin L, Hanada T, Chishti AH. VAM-1: a new member of the MAGUK family binds to human Veli-1 through a conserved domain. Biochim Biophys Acta. 2001 Apr 16; 1518(3):249-59. PMID: 11311936.
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    82. Azam M, Andrabi SS, Sahr KE, Kamath L, Kuliopulos A, Chishti AH. Disruption of the mouse mu-calpain gene reveals an essential role in platelet function. Mol Cell Biol. 2001 Mar; 21(6):2213-20. PMID: 11238954; PMCID: PMC86855.
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    83. Nix SL, Chishti AH, Anderson JM, Walther Z. hCASK and hDlg associate in epithelia, and their src homology 3 and guanylate kinase domains participate in both intramolecular and intermolecular interactions. J Biol Chem. 2000 Dec 29; 275(52):41192-200. PMID: 10993877.
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    84. Voigt S, Hanspal M, LeRoy PJ, Zhao PS, Oh SS, Chishti AH, Liu SC. The cytoadherence ligand Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) binds to the P. falciparum knob-associated histidine-rich protein (KAHRP) by electrostatic interactions. Mol Biochem Parasitol. 2000 Oct; 110(2):423-8. PMID: 11071296.
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    85. Raphael P, Takakuwa Y, Manno S, Liu SC, Chishti AH, Hanspal M. A cysteine protease activity from Plasmodium falciparum cleaves human erythrocyte ankyrin. Mol Biochem Parasitol. 2000 Oct; 110(2):259-72. PMID: 11071281.
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    86. Hanada T, Lin L, Tibaldi EV, Reinherz EL, Chishti AH. GAKIN, a novel kinesin-like protein associates with the human homologue of the Drosophila discs large tumor suppressor in T lymphocytes. J Biol Chem. 2000 Sep 15; 275(37):28774-84. PMID: 10859302.
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    87. Aradhya S, Ahobila P, Lewis RA, Nelson DL, Esposito T, Ciccodicola A, Bardaro T, D'Urso M, Woffendin H, Kenwrick S, Smahi A, Heuertz S, Munnich A, Heiss NS, Poustka A, Chishti AH. Filamin (FLN1), plexin (SEX), major palmitoylated protein p55 (MPP1), and von-Hippel Lindau binding protein (VBP1) are not involved in incontinentia pigmenti type 2. Am J Med Genet. 2000 Sep 4; 94(1):79-84. PMID: 10982489.
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    88. Marfatia SM, Byron O, Campbell G, Liu SC, Chishti AH. Human homologue of the Drosophila discs large tumor suppressor protein forms an oligomer in solution. Identification of the self-association site. J Biol Chem. 2000 May 5; 275(18):13759-70. PMID: 10788497.
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    89. Oh SS, Voigt S, Fisher D, Yi SJ, LeRoy PJ, Derick LH, Liu S, Chishti AH. Plasmodium falciparum erythrocyte membrane protein 1 is anchored to the actin-spectrin junction and knob-associated histidine-rich protein in the erythrocyte skeleton. Mol Biochem Parasitol. 2000 May; 108(2):237-47. PMID: 10838226.
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    90. Lutchman M, Pack S, Kim AC, Azim A, Emmert-Buck M, van Huffel C, Zhuang Z, Chishti AH. Loss of heterozygosity on 8p in prostate cancer implicates a role for dematin in tumor progression. Cancer Genet Cytogenet. 1999 Nov; 115(1):65-9. PMID: 10565303.
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    91. Azim AC, Kim AC, Lutchman M, Andrabi S, Peters LL, Chishti AH. cDNA sequence, genomic structure, and expression of the mouse dematin gene (Epb4.9). Mamm Genome. 1999 Oct; 10(10):1026-9. PMID: 10501976.
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    92. Ruff P, Chishti AH, Grimm E, Bischoff D, Kim AC. Exon skipping truncates the PDZ domain of human erythroid p55 in a patient with chronic myeloid leukemia in acute megakaryoblastic blast crisis. Leuk Res. 1999 Mar; 23(3):247-50. PMID: 10071076.
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    93. Lin L, Peters LL, Ciciotte SL, Chishti AH. cDNA sequence and chromosomal localization of mouse Dlgh3 gene adjacent to the BRCA1 tumor suppressor locus. Biochim Biophys Acta. 1998 Nov 26; 1443(1-2):211-6. PMID: 9838122.
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    94. Hassoun H, Wang Y, Vassiliadis J, Lutchman M, Palek J, Aish L, Aish IS, Liu SC, Chishti AH. Targeted inactivation of murine band 3 (AE1) gene produces a hypercoagulable state causing widespread thrombosis in vivo. Blood. 1998 Sep 1; 92(5):1785-92. PMID: 9716609.
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    95. Chishti AH, Kim AC, Marfatia SM, Lutchman M, Hanspal M, Jindal H, Liu SC, Low PS, Rouleau GA, Mohandas N, Chasis JA, Conboy JG, Gascard P, Takakuwa Y, Huang SC, Benz EJ, Bretscher A, Fehon RG, Gusella JF, Ramesh V, Solomon F, Marchesi VT, Tsukita S, Tsukita S, Hoover KB, et al. The FERM domain: a unique module involved in the linkage of cytoplasmic proteins to the membrane. Trends Biochem Sci. 1998 Aug; 23(8):281-2. PMID: 9757824.
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    96. Cohen AR, Woods DF, Marfatia SM, Walther Z, Chishti AH, Anderson JM, Wood DF. Human CASK/LIN-2 binds syndecan-2 and protein 4.1 and localizes to the basolateral membrane of epithelial cells. J Cell Biol. 1998 Jul 13; 142(1):129-38. PMID: 9660868; PMCID: PMC2133028.
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    97. Kim AC, Azim AC, Chishti AH. Alternative splicing and structure of the human erythroid dematin gene. Biochim Biophys Acta. 1998 Jul 9; 1398(3):382-6. PMID: 9655941.
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    98. Rafael JA, Hutchinson TL, Lumeng CN, Marfatia SM, Chishti AH, Chamberlain JS. Localization of Dlg at the mammalian neuromuscular junction. Neuroreport. 1998 Jun 22; 9(9):2121-5. PMID: 9674605.
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    99. Kim AC, Van Huffel C, Lutchman M, Chishti AH. Radiation hybrid mapping of EPB41L1, a novel protein 4.1 homologue, to human chromosome 20q11.2-q12. Genomics. 1998 Apr 1; 49(1):165-6. PMID: 9570967.
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    100. Hassoun H, Hanada T, Lutchman M, Sahr KE, Palek J, Hanspal M, Chishti AH. Complete deficiency of glycophorin A in red blood cells from mice with targeted inactivation of the band 3 (AE1) gene. Blood. 1998 Mar 15; 91(6):2146-51. PMID: 9490702.
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    101. Chishti AH. Function of p55 and its nonerythroid homologues. Curr Opin Hematol. 1998 Mar; 5(2):116-21. PMID: 9570704.
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    102. Kim E, DeMarco SJ, Marfatia SM, Chishti AH, Sheng M, Strehler EE. Plasma membrane Ca2+ ATPase isoform 4b binds to membrane-associated guanylate kinase (MAGUK) proteins via their PDZ (PSD-95/Dlg/ZO-1) domains. J Biol Chem. 1998 Jan 16; 273(3):1591-5. PMID: 9430700.
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    103. Kim AC, Peters LL, Knoll JH, Van Huffel C, Ciciotte SL, Kleyn PW, Chishti AH. Limatin (LIMAB1), an actin-binding LIM protein, maps to mouse chromosome 19 and human chromosome 10q25, a region frequently deleted in human cancers. Genomics. 1997 Dec 1; 46(2):291-3. PMID: 9417918.
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    104. Lin L, Sahr KE, Chishti AH. Identification of the mouse homologue of human discs large and rat SAP97 genes. Biochim Biophys Acta. 1997 Nov 28; 1362(1):1-5. PMID: 9434093.
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    105. Hanada T, Lin L, Chandy KG, Oh SS, Chishti AH. Human homologue of the Drosophila discs large tumor suppressor binds to p56lck tyrosine kinase and Shaker type Kv1.3 potassium channel in T lymphocytes. J Biol Chem. 1997 Oct 24; 272(43):26899-904. PMID: 9341123.
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    106. Alexander C, Stathakis DG, Lin L, Rahman S, Bryant PJ, Auburger G, Chishti AH. Fine scale mapping places DLG1, the gene encoding hDlg, telomeric to the OPA1 candidate region. Mamm Genome. 1997 Oct; 8(10):795-6. PMID: 9321488.
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    107. Marfatia SM, Morais-Cabral JH, Kim AC, Byron O, Chishti AH. The PDZ domain of human erythrocyte p55 mediates its binding to the cytoplasmic carboxyl terminus of glycophorin C. Analysis of the binding interface by in vitro mutagenesis. J Biol Chem. 1997 Sep 26; 272(39):24191-7. PMID: 9305870.
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    108. Roof DJ, Hayes A, Adamian M, Chishti AH, Li T. Molecular characterization of abLIM, a novel actin-binding and double zinc finger protein. J Cell Biol. 1997 Aug 11; 138(3):575-88. PMID: 9245787; PMCID: PMC2141644.
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    109. Oh SS, Chishti AH, Palek J, Liu SC. Erythrocyte membrane alterations in Plasmodium falciparum malaria sequestration. Curr Opin Hematol. 1997 Mar; 4(2):148-54. PMID: 9107533.
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    110. Songyang Z, Fanning AS, Fu C, Xu J, Marfatia SM, Chishti AH, Crompton A, Chan AC, Anderson JM, Cantley LC. Recognition of unique carboxyl-terminal motifs by distinct PDZ domains. Science. 1997 Jan 3; 275(5296):73-7. PMID: 8974395.
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    111. Elder B, Kuo K, Gitschier J, Kim A, Chishti A, Metzenberg A. cDNA sequence and genomic structure of the murine p55 (Mpp1) gene. Genomics. 1996 Dec 1; 38(2):231-4. PMID: 8954807.
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    112. Marfatia SM, Morais Cabral JH, Lin L, Hough C, Bryant PJ, Stolz L, Chishti AH. Modular organization of the PDZ domains in the human discs-large protein suggests a mechanism for coupling PDZ domain-binding proteins to ATP and the membrane cytoskeleton. J Cell Biol. 1996 Nov; 135(3):753-66. PMID: 8909548; PMCID: PMC2121072.
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    113. Southgate CD, Chishti AH, Mitchell B, Yi SJ, Palek J. Targeted disruption of the murine erythroid band 3 gene results in spherocytosis and severe haemolytic anaemia despite a normal membrane skeleton. Nat Genet. 1996 Oct; 14(2):227-30. PMID: 8841202.
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    114. Morais Cabral JH, Petosa C, Sutcliffe MJ, Raza S, Byron O, Poy F, Marfatia SM, Chishti AH, Liddington RC. Crystal structure of a PDZ domain. Nature. 1996 Aug 15; 382(6592):649-52. PMID: 8757139.
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    115. Peters LL, Ciciotte SL, Lin L, Chishti AH. The mouse homolog of the Drosophila discs large tumor suppressor gene maps to chromosome 16. Mamm Genome. 1996 Aug; 7(8):619-20. PMID: 8829552.
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    116. Chishti AH, Palek J, Fisher D, Maalouf GJ, Liu SC. Reduced invasion and growth of Plasmodium falciparum into elliptocytic red blood cells with a combined deficiency of protein 4.1, glycophorin C, and p55. Blood. 1996 Apr 15; 87(8):3462-9. PMID: 8605365.
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    117. Azim AC, Marfatia SM, Korsgren C, Dotimas E, Cohen CM, Chishti AH. Human erythrocyte dematin and protein 4.2 (pallidin) are ATP binding proteins. Biochemistry. 1996 Mar 5; 35(9):3001-6. PMID: 8608138.
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    118. Peters LL, Kirley LA, Kim AC, Chishti AH. Localization of the gene encoding the erythrocyte membrane protein p55 (Mpp1) on the mouse X Chromosome. Mamm Genome. 1996 Mar; 7(3):245-6. PMID: 8833260.
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    119. Kim AC, Metzenberg AB, Sahr KE, Marfatia SM, Chishti AH. Complete genomic organization of the human erythroid p55 gene (MPP1), a membrane-associated guanylate kinase homologue. Genomics. 1996 Jan 15; 31(2):223-9. PMID: 8824805.
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    120. Azim AC, Knoll JH, Marfatia SM, Peel DJ, Bryant PJ, Chishti AH. DLG1: chromosome location of the closest human homologue of the Drosophila discs large tumor suppressor gene. Genomics. 1995 Dec 10; 30(3):613-6. PMID: 8825652.
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    121. Azim AC, Knoll JH, Beggs AH, Chishti AH. Isoform cloning, actin binding, and chromosomal localization of human erythroid dematin, a member of the villin superfamily. J Biol Chem. 1995 Jul 21; 270(29):17407-13. PMID: 7615546.
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    122. Peters LL, Eicher EM, Azim AC, Chishti AH. The gene encoding the erythrocyte membrane skeleton protein dematin (Epb4.9) maps to mouse chromosome 14. Genomics. 1995 Apr 10; 26(3):634-5. PMID: 7607697.
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    123. Marfatia SM, Leu RA, Branton D, Chishti AH. Identification of the protein 4.1 binding interface on glycophorin C and p55, a homologue of the Drosophila discs-large tumor suppressor protein. J Biol Chem. 1995 Jan 13; 270(2):715-9. PMID: 7822301.
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    124. Lue RA, Marfatia SM, Branton D, Chishti AH. Cloning and characterization of hdlg: the human homologue of the Drosophila discs large tumor suppressor binds to protein 4.1. Proc Natl Acad Sci U S A. 1994 Oct 11; 91(21):9818-22. PMID: 7937897; PMCID: PMC44908.
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    125. Chishti AH, Maalouf GJ, Marfatia S, Palek J, Wang W, Fisher D, Liu SC. Phosphorylation of protein 4.1 in Plasmodium falciparum-infected human red blood cells. Blood. 1994 Jun 1; 83(11):3339-45. PMID: 8193370.
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    126. Marfatia SM, Lue RA, Branton D, Chishti AH. In vitro binding studies suggest a membrane-associated complex between erythroid p55, protein 4.1, and glycophorin C. J Biol Chem. 1994 Mar 25; 269(12):8631-4. PMID: 8132590.
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    127. Sahr KE, Coetzer TL, Moy LS, Derick LH, Chishti AH, Jarolim P, Lorenzo F, Miraglia del Giudice E, Iolascon A, Gallanello R, et al. Spectrin cagliari. an Ala-->Gly substitution in helix 1 of beta spectrin repeat 17 that severely disrupts the structure and self-association of the erythrocyte spectrin heterodimer. J Biol Chem. 1993 Oct 25; 268(30):22656-62. PMID: 8226774.
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    128. Alloisio N, Dalla Venezia N, Rana A, Andrabi K, Texier P, Gilsanz F, Cartron JP, Delaunay J, Chishti AH. Evidence that red blood cell protein p55 may participate in the skeleton-membrane linkage that involves protein 4.1 and glycophorin C. Blood. 1993 Aug 15; 82(4):1323-7. PMID: 8353290.
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    129. Rana AP, Ruff P, Maalouf GJ, Speicher DW, Chishti AH. Cloning of human erythroid dematin reveals another member of the villin family. Proc Natl Acad Sci U S A. 1993 Jul 15; 90(14):6651-5. PMID: 8341682; PMCID: PMC46990.
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    130. Chishti AH, Andrabi KI, Derick LH, Palek J, Liu SC. Isolation of skeleton-associated knobs from human red blood cells infected with malaria parasite Plasmodium falciparum. Mol Biochem Parasitol. 1992 Jun; 52(2):283-7. PMID: 1620167.
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    131. Derick LH, Liu SC, Chishti AH, Palek J. Protein immunolocalization in the spread erythrocyte membrane skeleton. Eur J Cell Biol. 1992 Apr; 57(2):317-20. PMID: 1387364.
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