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Last Name
Institution

Clifford J. Rosen

TitleProfessor
InstitutionMaine Medical Center
DepartmentMedicine
AddressMaine Medical Center Research Institute
81 Research Drive
Scarborough ME 04074
Phone(207) 396-8228
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Reagan MR, Lian JB, Rosen CJ, Stein GS. Cover Image, Volume 232, Number 12, December 2017. J Cell Physiol. 2017 Dec; 232(12):i. PMID: 28833120.
      View in: PubMed
    2. Maridas DE, DeMambro VE, Le PT, Mohan S, Rosen CJ. IGFBP4 Is Required for Adipogenesis and Influences the Distribution of Adipose Depots. Endocrinology. 2017 Oct 01; 158(10):3488-3500. PMID: 28938423.
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    3. Uchimura T, Hollander JM, Nakamura DS, Liu Z, Rosen CJ, Georgakoudi I, Zeng L. An essential role for IGF2 in cartilage development and glucose metabolism during postnatal long bone growth. Development. 2017 Oct 01; 144(19):3533-3546. PMID: 28974642.
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    4. Bornstein S, Moschetta M, Kawano Y, Sacco A, Huynh D, Brooks D, Manier S, Fairfield H, Falank C, Roccaro AM, Nagano K, Baron R, Bouxein M, Vary C, Ghobrial IM, Rosen CJ, Reagan MR. Metformin Affects Cortical Bone Mass and Marrow Adiposity in Diet-Induced Obesity in Male Mice. Endocrinology. 2017 Oct 01; 158(10):3369-3385. PMID: 28977604.
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    5. Liu Z, Han T, Werner H, Rosen CJ, Schaffler MB, Yakar S. Reduced serum IGF-1 associated with hepatic osteodystrophy is a main determinant of low cortical but not trabecular bone mass. J Bone Miner Res. 2017 Sep 13. PMID: 28902430.
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    6. Rosen CJ. Romosozumab - Promising or Practice Changing? N Engl J Med. 2017 Sep 11. PMID: 28892459.
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    7. Oxburgh L, Rosen CJ. New Insights into Fuel Choices of Nephron Progenitor Cells. J Am Soc Nephrol. 2017 Sep 05. PMID: 28874403.
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    8. Horowitz MC, Berry R, Holtrup B, Sebo Z, Nelson T, Fretz JA, Lindskog D, Kaplan JL, Ables G, Rodeheffer MS, Rosen CJ. Bone marrow adipocytes. Adipocyte. 2017 Aug 24; 1-12. PMID: 28872979.
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    9. Li X, Shet K, Xu K, Rodríguez JP, Pino AM, Kurhanewicz J, Schwartz A, Rosen CJ. Unsaturation level decreased in bone marrow fat of postmenopausal women with low bone density using high resolution magic angle spinning (HRMAS) 1H NMR spectroscopy. Bone. 2017 Aug 17. PMID: 28823880.
      View in: PubMed
    10. Rosen CJ, Zaidi M. Contemporaneous reproduction of preclinical science: a case study of FSH and fat. Ann N Y Acad Sci. 2017 Aug 15. PMID: 28810084.
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    11. Le PT, Bishop KA, Maridas DE, Motyl KJ, Brooks DJ, Nagano K, Baron R, Bouxsein ML, Rosen CJ. Spontaneous mutation of Dock7 results in lower trabecular bone mass and impaired periosteal expansion in aged female Misty mice. Bone. 2017 Aug 15. PMID: 28821457.
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    12. Rendina-Ruedy E, Guntur AR, Rosen CJ. Intracellular lipid droplets support osteoblast function. Adipocyte. 2017 Jul 20; 1-9. PMID: 28792783.
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    13. Motyl KJ, Beauchemin M, Barlow D, Le PT, Nagano K, Treyball A, Contractor A, Baron R, Rosen CJ, Houseknecht KL. A novel role for dopamine signaling in the pathogenesis of bone loss from the atypical antipsychotic drug risperidone in female mice. Bone. 2017 Jul 06; 103:168-176. PMID: 28689816.
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    14. Lee WC, Guntur AR, Long F, Rosen CJ. Energy Metabolism of the Osteoblast: Implications for Osteoporosis. Endocr Rev. 2017 Jun 01; 38(3):255-266. PMID: 28472361.
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    15. Liu P, Ji Y, Yuen T, Rendina-Ruedy E, DeMambro VE, Dhawan S, Abu-Amer W, Izadmehr S, Zhou B, Shin AC, Latif R, Thangeswaran P, Gupta A, Li J, Shnayder V, Robinson ST, Yu YE, Zhang X, Yang F, Lu P, Zhou Y, Zhu LL, Oberlin DJ, Davies TF, Reagan MR, Brown A, Kumar TR, Epstein S, Iqbal J, Avadhani NG, New MI, Molina H, van Klinken JB, Guo EX, Buettner C, Haider S, Bian Z, Sun L, Rosen CJ, Zaidi M. Blocking FSH induces thermogenic adipose tissue and reduces body fat. Nature. 2017 Jun 01; 546(7656):107-112. PMID: 28538730.
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    16. Cormier J, Cone K, Lanpher J, Kinens A, Henderson T, Liaw L, Bilsky EJ, King T, Rosen CJ, Stevenson GW. Exercise reverses pain-related weight asymmetry and differentially modulates trabecular bone microarchitecture in a rat model of osteoarthritis. Life Sci. 2017 May 11. PMID: 28504116.
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    17. Fairfield H, Falank C, Harris E, Demambro V, McDonald M, Pettitt JA, Mohanty ST, Croucher P, Kramer I, Kneissel M, Rosen CJ, Reagan MR. The skeletal cell-derived molecule sclerostin drives bone marrow adipogenesis. J Cell Physiol. 2017 Apr 29. PMID: 28460416.
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    18. Fairfield H, Rosen CJ, Reagan MR. Connecting Bone and Fat: The Potential Role for Sclerostin. Curr Mol Biol Rep. 2017 Jun; 3(2):114-121. PMID: 28580233.
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    19. Lanske B, Rosen C. Bone Marrow Adipose Tissue: The First 40 Years. J Bone Miner Res. 2017 Jun; 32(6):1153-1156. PMID: 28370194.
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    20. Lima JG, Nobrega LH, Lima NN, Dos Santos MC, Baracho MF, Winzenrieth R, Bandeira F, Mendes-Aguiar CO, Neto FP, Ferreira LC, Rosen CJ, Jeronimo SM. Normal bone density and trabecular bone score, but high serum sclerostin in congenital generalized lipodystrophy. Bone. 2017 Apr 05. PMID: 28390904.
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    21. Reagan MR, Lian J, Rosen CJ, Stein G. A Perspective on Malignancy in the Marrow. J Cell Physiol. 2017 Feb 16. PMID: 28206683.
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    22. Maridas DE, DeMambro VE, Le PT, Nagano K, Baron R, Mohan S, Rosen CJ. IGFBP-4 regulates adult skeletal growth in a sex-specific manner. J Endocrinol. 2017 Apr; 233(1):131-144. PMID: 28184001.
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    23. Dimitri P, Rosen C. Fat and Bone: Where are We Now? Calcif Tissue Int. 2017 May; 100(5):431-432. PMID: 28154889.
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    24. Fan Y, Hanai JI, Le PT, Bi R, Maridas D, DeMambro V, Figueroa CA, Kir S, Zhou X, Mannstadt M, Baron R, Bronson RT, Horowitz MC, Wu JY, Bilezikian JP, Dempster DW, Rosen CJ, Lanske B. Parathyroid Hormone Directs Bone Marrow Mesenchymal Cell Fate. Cell Metab. 2017 Mar 07; 25(3):661-672. PMID: 28162969.
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    25. Jin YR, Stohn JP, Wang Q, Nagano K, Baron R, Bouxsein ML, Rosen CJ, Adarichev VA, Lindner V. Inhibition of osteoclast differentiation and collagen antibody-induced arthritis by CTHRC1. Bone. 2017 Jan 21; 97:153-167. PMID: 28115279.
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    26. Khosla S, Cauley JA, Compston J, Kiel DP, Rosen C, Saag KG, Shane E. Addressing the Crisis in the Treatment of Osteoporosis: A Path Forward. J Bone Miner Res. 2016 Dec 29. PMID: 28099754.
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    27. Scheller EL, Doucette CR, Learman BS, Cawthorn WP, Khandaker S, Schell B, Wu B, Ding SY, Bredella MA, Fazeli PK, Khoury B, Jepsen KJ, Pilch PF, Klibanski A, Rosen CJ, MacDougald OA. Corrigendum: Region-specific variation in the properties of skeletal adipocytes reveals regulated and constitutive marrow adipose tissues. Nat Commun. 2016 Dec 08; 7:13775. PMID: 27929114.
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    28. Veldhuis-Vlug AG, Rosen CJ. Mechanisms of marrow adiposity and its implications for skeletal health. Metabolism. 2017 Feb; 67:106-114. PMID: 28081773.
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    29. Rendina-Ruedy E, Rosen CJ. Bone-Fat Interaction. Endocrinol Metab Clin North Am. 2017 Mar; 46(1):41-50. PMID: 28131135.
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    30. Calabrese GM, Mesner LD, Stains JP, Tommasini SM, Horowitz MC, Rosen CJ, Farber CR. Integrating GWAS and Co-expression Network Data Identifies Bone Mineral Density Genes SPTBN1 and MARK3 and an Osteoblast Functional Module. Cell Syst. 2016 Nov 15. PMID: 27866947.
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    31. Manson JE, Brannon PM, Rosen CJ, Taylor CL. Vitamin D Deficiency - Is There Really a Pandemic? N Engl J Med. 2016 Nov 10; 375(19):1817-1820. PMID: 27959647.
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    32. Gordon CM, Zemel BS, Wren TA, Leonard MB, Bachrach LK, Rauch F, Gilsanz V, Rosen CJ, Winer KK. The Determinants of Peak Bone Mass. J Pediatr. 2016 Nov 3. PMID: 27816219.
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    33. Liu JM, Rosen CJ, Ducy P, Kousteni S, Karsenty G. Regulation of Glucose Handling by the Skeleton: Insights From Mouse and Human Studies. Diabetes. 2016 Nov; 65(11):3225-3232. PMID: 27959858.
      View in: PubMed
    34. Pino AM, Miranda M, Figueroa C, Rodríguez JP, Rosen CJ. Qualitative Aspects of Bone Marrow Adiposity in Osteoporosis. Front Endocrinol (Lausanne). 2016; 7:139. PMID: 27826285.
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    35. Dadwal U, Falank C, Fairfield H, Linehan S, Rosen CJ, Kaplan DL, Sterling J, Reagan MR. Tissue-engineered 3D cancer-in-bone modeling: silk and PUR protocols. Bonekey Rep. 2016; 5:842. PMID: 27790370.
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    36. Román F, Urra C, Porras O, Pino AM, Rosen CJ, Rodríguez JP. Real-Time H2 O2 Measurements in Bone Marrow Mesenchymal Stem Cells (MSCs) Show Increased Antioxidant Capacity in Cells From Osteoporotic Women. J Cell Biochem. 2017 Mar; 118(3):585-593. PMID: 27632788.
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    37. Dhaliwal R, Rosen CJ. Type 2 Diabetes and Aging: A Not so Sweet Scenario for Bone. Horm Metab Res. 2016 Oct 11. PMID: 27728926.
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    38. Rosen CJ, Ingelfinger JR. Building Better Bones with Biologics - A New Approach to Osteoporosis? N Engl J Med. 2016 Oct 20; 375(16):1583-1584. PMID: 27641359.
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    39. Garfinkel BP, Arad S, Neuner SM, Netser S, Wagner S, Kaczorowski CC, Rosen CJ, Gal M, Soreq H, Orly J. HP1BP3 expression determines maternal behavior and offspring survival. Genes Brain Behav. 2016 Sep; 15(7):678-88. PMID: 27470444.
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    40. Dimitri P, Rosen C. The Central Nervous System and Bone Metabolism: An Evolving Story. Calcif Tissue Int. 2017 May; 100(5):476-485. PMID: 27501818.
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    41. Bishop KA, Harrington A, Kouranova E, Weinstein EJ, Rosen CJ, Cui X, Liaw L. CRISPR/Cas9-Mediated Insertion of loxP Sites in the Mouse Dock7 Gene Provides an Effective Alternative to Use of Targeted Embryonic Stem Cells. G3 (Bethesda). 2016; 6(7):2051-61. PMID: 27175020.
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    42. Calabrese G, Mesner LD, Foley PL, Rosen CJ, Farber CR. Network Analysis Implicates Alpha-Synuclein (Snca) in the Regulation of Ovariectomy-Induced Bone Loss. Sci Rep. 2016; 6:29475. PMID: 27378017.
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    43. Stechschulte LA, Czernik PJ, Rotter ZC, Tausif FN, Corzo CA, Marciano DP, Asteian A, Zheng J, Bruning JB, Kamenecka TM, Rosen CJ, Griffin PR, Lecka-Czernik B. PPARG Post-translational Modifications Regulate Bone Formation and Bone Resorption. EBioMedicine. 2016 Aug; 10:174-84. PMID: 27422345.
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    44. Veld J, O'Donnell EK, Reagan MR, Yee AJ, Torriani M, Rosen CJ, Bredella MA. Abdominal adipose tissue in MGUS and multiple myeloma. Skeletal Radiol. 2016 Sep; 45(9):1277-83. PMID: 27344672.
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    45. Ingelfinger JR, Rosen CJ. Cardiac and Renovascular Complications in Type 2 Diabetes--Is There Hope? N Engl J Med. 2016 Jul 28; 375(4):380-2. PMID: 27331286.
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    46. Devlin MJ, Brooks DJ, Conlon C, Vliet Mv, Louis L, Rosen CJ, Bouxsein ML. Daily leptin blunts marrow fat but does not impact bone mass in calorie-restricted mice. J Endocrinol. 2016 Jun; 229(3):295-306. PMID: 27340200.
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    47. Black DM, Rosen CJ. Postmenopausal Osteoporosis. N Engl J Med. 2016 May 26; 374(21):2096-7. PMID: 27223157.
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    48. Iwaniec UT, Philbrick KA, Wong CP, Gordon JL, Kahler-Quesada AM, Olson DA, Branscum AJ, Sargent JL, DeMambro VE, Rosen CJ, Turner RT. Room temperature housing results in premature cancellous bone loss in growing female mice: implications for the mouse as a preclinical model for age-related bone loss. Osteoporos Int. 2016 Oct; 27(10):3091-101. PMID: 27189604.
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    49. Miranda M, Pino AM, Fuenzalida K, Rosen CJ, Seitz G, Rodríguez JP. Characterization of Fatty Acid Composition in Bone Marrow Fluid From Postmenopausal Women: Modification After Hip Fracture. J Cell Biochem. 2016 Oct; 117(10):2370-6. PMID: 27416518.
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    50. Liaw L, Prudovsky I, Koza RA, Anunciado-Koza RV, Siviski ME, Lindner V, Friesel RE, Rosen CJ, Baker PR, Simons B, Vary CP. Lipid Profiling of In Vitro Cell Models of Adipogenic Differentiation: Relationships With Mouse Adipose Tissues. J Cell Biochem. 2016 Sep; 117(9):2182-93. PMID: 26910604.
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    51. Xi G, Shen X, Rosen CJ, Clemmons DR. IRS-1 Functions as a Molecular Scaffold to Coordinate IGF-I/IGFBP-2 Signaling During Osteoblast Differentiation. J Bone Miner Res. 2016 Jun; 31(6):1300-14. PMID: 26773517.
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    52. Black DM, Rosen CJ. Postmenopausal Osteoporosis. N Engl J Med. 2016 Jan 21; 374(3):254-62. PMID: 26789873.
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    53. Ackert-Bicknell CL, Rosen CJ. Passenger Gene Mutations: Unwanted Guests in Genetically Modified Mice. J Bone Miner Res. 2016 Feb; 31(2):270-3. PMID: 26684928.
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    54. Hardouin P, Marie PJ, Rosen CJ. New insights into bone marrow adipocytes: Report from the First European Meeting on Bone Marrow Adiposity (BMA 2015). Bone. 2016 Dec; 93:212-215. PMID: 26608519.
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    55. Reagan MR, Rosen CJ. Navigating the bone marrow niche: translational insights and cancer-driven dysfunction. Nat Rev Rheumatol. 2016 Mar; 12(3):154-68. PMID: 26607387.
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    56. Ingelfinger JR, Rosen CJ. Cardiovascular Risk and Sodium-Glucose Cotransporter 2 Inhibition in Type 2 Diabetes. N Engl J Med. 2015 Nov 26; 373(22):2178-9. PMID: 26605932.
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    57. Xi G, Rosen CJ, Clemmons DR. IGF-I and IGFBP-2 Stimulate AMPK Activation and Autophagy, Which Are Required for Osteoblast Differentiation. Endocrinology. 2016 Jan; 157(1):268-81. PMID: 26556533.
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    58. Turner RT, Dube M, Branscum AJ, Wong CP, Olson DA, Zhong X, Kweh MF, Larkin IV, Wronski TJ, Rosen CJ, Kalra SP, Iwaniec UT. Hypothalamic leptin gene therapy reduces body weight without accelerating age-related bone loss. J Endocrinol. 2015 Dec; 227(3):129-41. PMID: 26487675.
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    59. Liu Z, Kennedy OD, Cardoso L, Basta-Pljakic J, Partridge NC, Schaffler MB, Rosen CJ, Yakar S. DMP-1-mediated Ghr gene recombination compromises skeletal development and impairs skeletal response to intermittent PTH. FASEB J. 2016 Feb; 30(2):635-52. PMID: 26481310.
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    60. Garfinkel BP, Arad S, Le PT, Bustin M, Rosen CJ, Gabet Y, Orly J. Proportionate Dwarfism in Mice Lacking Heterochromatin Protein 1 Binding Protein 3 (HP1BP3) Is Associated With Alterations in the Endocrine IGF-1 Pathway. Endocrinology. 2015 Dec; 156(12):4558-70. PMID: 26402843.
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    61. Shanbhogue VV, Mitchell DM, Rosen CJ, Bouxsein ML. Type 2 diabetes and the skeleton: new insights into sweet bones. Lancet Diabetes Endocrinol. 2016 Feb; 4(2):159-73. PMID: 26365605.
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    62. Bouillon R, Drucker DJ, Ferrannini E, Grinspoon S, Rosen CJ, Zimmet P. The past 10 years-new hormones, new functions, new endocrine organs. Nat Rev Endocrinol. 2015 Nov; 11(11):681-6. PMID: 26323661.
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    63. Doucette CR, Horowitz MC, Berry R, MacDougald OA, Anunciado-Koza R, Koza RA, Rosen CJ. A High Fat Diet Increases Bone Marrow Adipose Tissue (MAT) But Does Not Alter Trabecular or Cortical Bone Mass in C57BL/6J Mice. J Cell Physiol. 2015 Sep; 230(9):2032-7. PMID: 25663195.
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    64. Rosen CJ, Ingelfinger JR. Unraveling the Function of FTO Variants. N Engl J Med. 2015 Sep 3; 373(10):964-5. PMID: 26287747.
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    65. Scheller EL, Doucette CR, Learman BS, Cawthorn WP, Khandaker S, Schell B, Wu B, Ding SY, Bredella MA, Fazeli PK, Khoury B, Jepsen KJ, Pilch PF, Klibanski A, Rosen CJ, MacDougald OA. Region-specific variation in the properties of skeletal adipocytes reveals regulated and constitutive marrow adipose tissues. Nat Commun. 2015; 6:7808. PMID: 26245716.
      View in: PubMed
    66. DeMambro VE, Le PT, Guntur AR, Maridas DE, Canalis E, Nagano K, Baron R, Clemmons DR, Rosen CJ. Igfbp2 Deletion in Ovariectomized Mice Enhances Energy Expenditure but Accelerates Bone Loss. Endocrinology. 2015 Nov; 156(11):4129-40. PMID: 26230658.
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    67. Lecka-Czernik B, Rosen CJ. Skeletal integration of energy homeostasis: Translational implications. Bone. 2016 Jan; 82:35-41. PMID: 26211994.
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    68. Lecka-Czernik B, Rosen CJ. Energy Excess, Glucose Utilization, and Skeletal Remodeling: New Insights. J Bone Miner Res. 2015 Aug; 30(8):1356-61. PMID: 26094610.
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    69. Berry R, Rodeheffer MS, Rosen CJ, Horowitz MC. Adipose Tissue Residing Progenitors (Adipocyte Lineage Progenitors and Adipose Derived Stem Cells (ADSC). Curr Mol Biol Rep. 2015 Sep; 1(3):101-109. PMID: 26526875.
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    70. Stohn JP, Wang Q, Siviski ME, Kennedy K, Jin YR, Kacer D, DeMambro V, Liaw L, Vary CP, Rosen CJ, Prudovsky I, Lindner V. Cthrc1 controls adipose tissue formation, body composition, and physical activity. Obesity (Silver Spring). 2015 Aug; 23(8):1633-42. PMID: 26148471.
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    71. Taylor CL, Thomas PR, Aloia JF, Millard PS, Rosen CJ. Questions About Vitamin D for Primary Care Practice: Input From an NIH Conference. Am J Med. 2015 Nov; 128(11):1167-70. PMID: 26071820.
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    72. Klein GL, Herndon DN, Le PT, Andersen CR, Benjamin D, Rosen CJ. The effect of burn on serum concentrations of sclerostin and FGF23. Burns. 2015 Nov; 41(7):1532-5. PMID: 25922302.
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    73. Sharma A, Flom PL, Rosen CJ, Schoenbaum EE. Racial differences in bone loss and relation to menopause among HIV-infected and uninfected women. Bone. 2015 Aug; 77:24-30. PMID: 25896953.
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    74. Fazeli PK, Faje AT, Cross EJ, Lee H, Rosen CJ, Bouxsein ML, Klibanski A. Serum FGF-21 levels are associated with worsened radial trabecular bone microarchitecture and decreased radial bone strength in women with anorexia nervosa. Bone. 2015 Aug; 77:6-11. PMID: 25868802.
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    75. Motyl KJ, DeMambro VE, Barlow D, Olshan D, Nagano K, Baron R, Rosen CJ, Houseknecht KL. Propranolol Attenuates Risperidone-Induced Trabecular Bone Loss in Female Mice. Endocrinology. 2015 Jul; 156(7):2374-83. PMID: 25853667.
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    76. Reagan MR, Liaw L, Rosen CJ, Ghobrial IM. Dynamic interplay between bone and multiple myeloma: emerging roles of the osteoblast. Bone. 2015 Jun; 75:161-9. PMID: 25725265.
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    77. Swanson CM, Shea SA, Stone KL, Cauley JA, Rosen CJ, Redline S, Karsenty G, Orwoll ES. Obstructive sleep apnea and metabolic bone disease: insights into the relationship between bone and sleep. J Bone Miner Res. 2015 Feb; 30(2):199-211. PMID: 25639209.
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    78. Guntur AR, Doucette CR, Rosen CJ. PTHrp comes full circle in cancer biology. Bonekey Rep. 2015; 4:621. PMID: 25628883.
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    79. Zaidi M, Rosen C, Zallone A. In memoriam: the life and works of itai bab (1945-2014). J Bone Miner Res. 2015 Jan; 30(1):1-2. PMID: 25545175.
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    80. Hui SK, Arentsen L, Sueblinvong T, Brown K, Bolan P, Ghebre RG, Downs L, Shanley R, Hansen KE, Minenko AG, Takhashi Y, Yagi M, Zhang Y, Geller M, Reynolds M, Lee CK, Blaes AH, Allen S, Zobel BB, Le C, Froelich J, Rosen C, Yee D. A phase I feasibility study of multi-modality imaging assessing rapid expansion of marrow fat and decreased bone mineral density in cancer patients. Bone. 2015 Apr; 73:90-7. PMID: 25536285.
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    81. Doucette CR, Rosen CJ. Inducible models of bone loss. Curr Protoc Mouse Biol. 2014; 4(4):165-80. PMID: 25723184.
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    82. Ma YH, Schwartz AV, Sigurdsson S, Hue TF, Lang TF, Harris TB, Rosen CJ, Vittinghoff E, Eiriksdottir G, Hauksdottir AM, Siggeirsdottir K, Sigurdsson G, Oskarsdottir D, Napoli N, Palermo L, Gudnason V, Li X. Circulating sclerostin associated with vertebral bone marrow fat in older men but not women. J Clin Endocrinol Metab. 2014 Dec; 99(12):E2584-90. PMID: 25144629.
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    83. Xi G, Wai C, DeMambro V, Rosen CJ, Clemmons DR. IGFBP-2 directly stimulates osteoblast differentiation. J Bone Miner Res. 2014 Nov; 29(11):2427-38. PMID: 24839202.
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    84. Pittas AG, Dawson-Hughes B, Sheehan PR, Rosen CJ, Ware JH, Knowler WC, Staten MA. Rationale and design of the vitamin d and type 2 diabetes (d2d) study: a diabetes prevention trial. Diabetes Care. 2014 Dec; 37(12):3227-34. PMID: 25205139; PMCID: PMC4237973 [Available on 12/01/15].
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      View in: PubMed Central
    85. Bonnet N, Somm E, Rosen CJ. Diet and gene interactions influence the skeletal response to polyunsaturated fatty acids. Bone. 2014 Nov; 68:100-7. PMID: 25088402.
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    86. Nallamshetty S, Le PT, Wang H, Issacsohn MJ, Reeder DJ, Rhee EJ, Kiefer FW, Brown JD, Rosen CJ, Plutzky J. Retinaldehyde dehydrogenase 1 deficiency inhibits PPAR?-mediated bone loss and marrow adiposity. Bone. 2014 Oct; 67:281-91. PMID: 25064526; NIHMSID: NIHMS616760 [Available on 10/01/15].
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    87. Devlin MJ, Van Vliet M, Motyl K, Karim L, Brooks DJ, Louis L, Conlon C, Rosen CJ, Bouxsein ML. Early-onset type 2 diabetes impairs skeletal acquisition in the male TALLYHO/JngJ mouse. Endocrinology. 2014 Oct; 155(10):3806-16. PMID: 25051433; PMCID: PMC4164927 [Available on 10/01/15].
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      View in: PubMed Central
    88. Bredella MA, Fazeli PK, Daley SM, Miller KK, Rosen CJ, Klibanski A, Torriani M. Marrow fat composition in anorexia nervosa. Bone. 2014 Sep; 66:199-204. PMID: 24953711; NIHMSID: NIHMS607122 [Available on 09/01/15].
      View in: PubMed
    89. Bornstein S, Brown SA, Le PT, Wang X, DeMambro V, Horowitz MC, MacDougald O, Baron R, Lotinun S, Karsenty G, Wei W, Ferron M, Kovacs CS, Clemmons D, Wan Y, Rosen CJ. FGF-21 and skeletal remodeling during and after lactation in C57BL/6J mice. Endocrinology. 2014 Sep; 155(9):3516-26. PMID: 24914939; PMCID: PMC4138567 [Available on 09/01/15].
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    90. Mesner LD, Ray B, Hsu YH, Manichaikul A, Lum E, Bryda EC, Rich SS, Rosen CJ, Criqui MH, Allison M, Budoff MJ, Clemens TL, Farber CR. Bicc1 is a genetic determinant of osteoblastogenesis and bone mineral density. J Clin Invest. 2014 Jun 2; 124(6):2736-49. PMID: 24789909; PMCID: PMC4038574.
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      View in: PubMed Central
    91. Rosen CJ, Taylor CL. Vitamin D supplementation and fall risk. Lancet Diabetes Endocrinol. 2014 Jul; 2(7):532-4. PMID: 24768504.
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    92. Scheller EL, Rosen CJ. What's the matter with MAT? Marrow adipose tissue, metabolism, and skeletal health. Ann N Y Acad Sci. 2014 Apr; 1311:14-30. PMID: 24650218; NIHMSID: NIHMS593631.
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    93. Yagi M, Arentsen L, Shanley RM, Rosen CJ, Kidder LS, Sharkey LC, Yee D, Koizumi M, Ogawa K, Hui SK. A dual-radioisotope hybrid whole-body micro-positron emission tomography/computed tomography system reveals functional heterogeneity and early local and systemic changes following targeted radiation to the murine caudal skeleton. Calcif Tissue Int. 2014 May; 94(5):544-52. PMID: 24562595; NIHMSID: NIHMS569788 [Available on 05/01/15].
      View in: PubMed
    94. Devlin MJ, Rosen CJ. The bone-fat interface: basic and clinical implications of marrow adiposity. Lancet Diabetes Endocrinol. 2015 Feb; 3(2):141-7. PMID: 24731667.
      View in: PubMed
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    185. Beamer WG, Shultz KL, Coombs HF, DeMambro VE, Reinholdt LG, Ackert-Bicknell CL, Canalis E, Rosen CJ, Donahue LR. BMD regulation on mouse distal chromosome 1, candidate genes, and response to ovariectomy or dietary fat. J Bone Miner Res. 2011 Jan; 26(1):88-99. PMID: 20687154; PMCID: PMC3179313.
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    186. Bredella MA, Torriani M, Ghomi RH, Thomas BJ, Brick DJ, Gerweck AV, Harrington LM, Breggia A, Rosen CJ, Miller KK. Determinants of bone mineral density in obese premenopausal women. Bone. 2011 Apr 1; 48(4):748-54. PMID: 21195217; NIHMSID: NIHMS262019.
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    187. Rosen CJ, Manson JE. Frailty: a D-ficiency syndrome of aging? J Clin Endocrinol Metab. 2010 Dec; 95(12):5210-2. PMID: 21131543.
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    188. Ross AC, Manson JE, Abrams SA, Aloia JF, Brannon PM, Clinton SK, Durazo-Arvizu RA, Gallagher JC, Gallo RL, Jones G, Kovacs CS, Mayne ST, Rosen CJ, Shapses SA. The 2011 report on dietary reference intakes for calcium and vitamin D from the Institute of Medicine: what clinicians need to know. J Clin Endocrinol Metab. 2011 Jan; 96(1):53-8. PMID: 21118827; PMCID: PMC3046611.
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    189. de Paula FJ, Horowitz MC, Rosen CJ. Novel insights into the relationship between diabetes and osteoporosis. Diabetes Metab Res Rev. 2010 Nov; 26(8):622-30. PMID: 20938995; NIHMSID: NIHMS239591.
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    192. Kawai M, Rosen CJ. PPAR?: a circadian transcription factor in adipogenesis and osteogenesis. Nat Rev Endocrinol. 2010 Nov; 6(11):629-36. PMID: 20820194; NIHMSID: NIHMS303877.
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    193. Courtland HW, DeMambro V, Maynard J, Sun H, Elis S, Rosen C, Yakar S. Sex-specific regulation of body size and bone slenderness by the acid labile subunit. J Bone Miner Res. 2010 Sep; 25(9):2059-68. PMID: 20499371; NIHMSID: NIHMS301964.
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    194. Elis S, Courtland HW, Wu Y, Fritton JC, Sun H, Rosen CJ, Yakar S. Elevated serum IGF-1 levels synergize PTH action on the skeleton only when the tissue IGF-1 axis is intact. J Bone Miner Res. 2010 Sep; 25(9):2051-8. PMID: 20499370; NIHMSID: NIHMS301968.
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    195. Devlin MJ, Cloutier AM, Thomas NA, Panus DA, Lotinun S, Pinz I, Baron R, Rosen CJ, Bouxsein ML. Caloric restriction leads to high marrow adiposity and low bone mass in growing mice. J Bone Miner Res. 2010 Sep; 25(9):2078-88. PMID: 20229598; NIHMSID: NIHMS301961.
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    198. Rosen CJ, Motyl KJ. No bones about it: insulin modulates skeletal remodeling. Cell. 2010 Jul 23; 142(2):198-200. PMID: 20655463.
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    199. Rosen CJ. Revisiting the rosiglitazone story--lessons learned. N Engl J Med. 2010 Aug 26; 363(9):803-6. PMID: 20660395.
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    200. Kawai M, Rosen CJ. Minireview: A skeleton in serotonin's closet? Endocrinology. 2010 Sep; 151(9):4103-8. PMID: 20660061; PMCID: PMC2940494.
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    202. Kawai M, Green CB, Lecka-Czernik B, Douris N, Gilbert MR, Kojima S, Ackert-Bicknell C, Garg N, Horowitz MC, Adamo ML, Clemmons DR, Rosen CJ. A circadian-regulated gene, Nocturnin, promotes adipogenesis by stimulating PPAR-gamma nuclear translocation. Proc Natl Acad Sci U S A. 2010 Jun 8; 107(23):10508-13. PMID: 20498072; PMCID: PMC2890788.
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    203. Bredella MA, Torriani M, Ghomi RH, Thomas BJ, Brick DJ, Gerweck AV, Rosen CJ, Klibanski A, Miller KK. Vertebral bone marrow fat is positively associated with visceral fat and inversely associated with IGF-1 in obese women. Obesity (Silver Spring). 2011 Jan; 19(1):49-53. PMID: 20467419; NIHMSID: NIHMS449887.
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    205. Urs S, Venkatesh D, Tang Y, Henderson T, Yang X, Friesel RE, Rosen CJ, Liaw L. Sprouty1 is a critical regulatory switch of mesenchymal stem cell lineage allocation. FASEB J. 2010 Sep; 24(9):3264-73. PMID: 20410440; PMCID: PMC2923355.
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    207. Menagh PJ, Turner RT, Jump DB, Wong CP, Lowry MB, Yakar S, Rosen CJ, Iwaniec UT. Growth hormone regulates the balance between bone formation and bone marrow adiposity. J Bone Miner Res. 2010 Apr; 25(4):757-68. PMID: 19821771; PMCID: PMC3153330.
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    208. de Paula FJ, Rosen CJ. Developing drugs to treat osteoporosis: lessons learned? Expert Opin Pharmacother. 2010 Apr; 11(5):867-9. PMID: 20113199.
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    209. de Paula FJ, Rosen CJ. Back to the future: revisiting parathyroid hormone and calcitonin control of bone remodeling. Horm Metab Res. 2010 May; 42(5):299-306. PMID: 20217631.
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    213. Ecklund K, Vajapeyam S, Feldman HA, Buzney CD, Mulkern RV, Kleinman PK, Rosen CJ, Gordon CM. Bone marrow changes in adolescent girls with anorexia nervosa. J Bone Miner Res. 2010 Feb; 25(2):298-304. PMID: 19653811; PMCID: PMC3153386.
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    215. Fritton JC, Emerton KB, Sun H, Kawashima Y, Mejia W, Wu Y, Rosen CJ, Panus D, Bouxsein M, Majeska RJ, Schaffler MB, Yakar S. Growth hormone protects against ovariectomy-induced bone loss in states of low circulating insulin-like growth factor (IGF-1). J Bone Miner Res. 2010 Feb; 25(2):235-46. PMID: 19619004; PMCID: PMC3153382.
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    216. Kerver JM, Gardiner JC, Dorgan JF, Rosen CJ, Velie EM. Dietary predictors of the insulin-like growth factor system in adolescent females: results from the Dietary Intervention Study in Children (DISC). Am J Clin Nutr. 2010 Mar; 91(3):643-50. PMID: 20089725; PMCID: PMC2824156.
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    217. Russell M, Mendes N, Miller KK, Rosen CJ, Lee H, Klibanski A, Misra M. Visceral fat is a negative predictor of bone density measures in obese adolescent girls. J Clin Endocrinol Metab. 2010 Mar; 95(3):1247-55. PMID: 20080853; PMCID: PMC2841531.
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    218. DeMambro VE, Kawai M, Clemens TL, Fulzele K, Maynard JA, Marín de Evsikova C, Johnson KR, Canalis E, Beamer WG, Rosen CJ, Donahue LR. A novel spontaneous mutation of Irs1 in mice results in hyperinsulinemia, reduced growth, low bone mass and impaired adipogenesis. J Endocrinol. 2010 Mar; 204(3):241-53. PMID: 20032200; NIHMSID: NIHMS182321.
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    219. Fritton JC, Kawashima Y, Mejia W, Courtland HW, Elis S, Sun H, Wu Y, Rosen CJ, Clemmons D, Yakar S. The insulin-like growth factor-1 binding protein acid-labile subunit alters mesenchymal stromal cell fate. J Biol Chem. 2010 Feb 12; 285(7):4709-14. PMID: 20007694; PMCID: PMC2836075.
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    220. Zaidi M, Turner CH, Canalis E, Pacifici R, Sun L, Iqbal J, Guo XE, Silverman S, Epstein S, Rosen CJ. Bone loss or lost bone: rationale and recommendations for the diagnosis and treatment of early postmenopausal bone loss. Curr Osteoporos Rep. 2009 Dec; 7(4):118-26. PMID: 19968915.
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    221. Rosen CJ. Bone: serotonin, leptin and the central control of bone remodeling. Nat Rev Rheumatol. 2009 Dec; 5(12):657-8. PMID: 19946292.
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    224. Rosen CJ. Leptin's RIGHT turn to the brain stem. Cell Metab. 2009 Oct; 10(4):243-4. PMID: 19808015.
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    225. Yakar S, Canalis E, Sun H, Mejia W, Kawashima Y, Nasser P, Courtland HW, Williams V, Bouxsein M, Rosen C, Jepsen KJ. Serum IGF-1 determines skeletal strength by regulating subperiosteal expansion and trait interactions. J Bone Miner Res. 2009 Aug; 24(8):1481-92. PMID: 19257833; PMCID: PMC2718800.
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    226. Hu D, Pawlikowska L, Kanaya A, Hsueh WC, Colbert L, Newman AB, Satterfield S, Rosen C, Cummings SR, Harris TB, Ziv E. Serum insulin-like growth factor-1 binding proteins 1 and 2 and mortality in older adults: the Health, Aging, and Body Composition Study. J Am Geriatr Soc. 2009 Jul; 57(7):1213-8. PMID: 19558480; NIHMSID: NIHMS136935.
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    227. Kawai M, Devlin MJ, Rosen CJ. Fat targets for skeletal health. Nat Rev Rheumatol. 2009 Jul; 5(7):365-72. PMID: 19468288; NIHMSID: NIHMS469060.
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    228. Mödder UI, Monroe DG, Fraser DG, Spelsberg TC, Rosen CJ, Géhin M, Chambon P, O'Malley BW, Khosla S. Skeletal consequences of deletion of steroid receptor coactivator-2/transcription intermediary factor-2. J Biol Chem. 2009 Jul 10; 284(28):18767-77. PMID: 19423703; PMCID: PMC2707192.
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    229. Rosen CJ, Klibanski A. Bone, fat, and body composition: evolving concepts in the pathogenesis of osteoporosis. Am J Med. 2009 May; 122(5):409-14. PMID: 19375545.
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    232. Kuhl LN, Ettinger B, Rosen CJ, Col NF. Questioning the accuracy of a recent review of osteoporosis medications. Ann Intern Med. 2009 Mar 17; 150(6):423-4; author reply 424-5. PMID: 19293078.
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    233. Rosen CJ. Serotonin rising--the bone, brain, bowel connection. N Engl J Med. 2009 Mar 5; 360(10):957-9. PMID: 19264685.
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    234. Maddalozzo GF, Turner RT, Edwards CH, Howe KS, Widrick JJ, Rosen CJ, Iwaniec UT. Alcohol alters whole body composition, inhibits bone formation, and increases bone marrow adiposity in rats. Osteoporos Int. 2009 Sep; 20(9):1529-38. PMID: 19238309.
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    235. Shockley KR, Lazarenko OP, Czernik PJ, Rosen CJ, Churchill GA, Lecka-Czernik B. PPARgamma2 nuclear receptor controls multiple regulatory pathways of osteoblast differentiation from marrow mesenchymal stem cells. J Cell Biochem. 2009 Feb 1; 106(2):232-46. PMID: 19115254; NIHMSID: NIHMS136773.
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    236. Rosen CJ. Breaking into bone biology: serotonin's secrets. Nat Med. 2009 Feb; 15(2):145-6. PMID: 19197289.
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    237. Nelson ML, Blum JM, Hollis BW, Rosen C, Sullivan SS. Supplements of 20 microg/d cholecalciferol optimized serum 25-hydroxyvitamin D concentrations in 80% of premenopausal women in winter. J Nutr. 2009 Mar; 139(3):540-6. PMID: 19158226.
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    238. Delahunty KM, Horton LG, Coombs HF, Shultz KL, Svenson KL, Marion MA, Holick MF, Beamer WG, Rosen CJ. Gender- and compartment-specific bone loss in C57BL/6J mice: correlation to season? J Clin Densitom. 2009 Jan-Mar; 12(1):89-94. PMID: 19195621; NIHMSID: NIHMS357029.
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    240. Rosen CJ, Ackert-Bicknell C, Rodriguez JP, Pino AM. Marrow fat and the bone microenvironment: developmental, functional, and pathological implications. Crit Rev Eukaryot Gene Expr. 2009; 19(2):109-24. PMID: 19392647; NIHMSID: NIHMS77529.
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    241. Rosen CJ. Sugar and bone: a not-so sweet story. J Bone Miner Res. 2008 Dec; 23(12):1881-3. PMID: 18847335; NIHMSID: NIHMS77522.
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    242. Kawai M, Rosen CJ. Insulin-like growth factor-I and bone: lessons from mice and men. Pediatr Nephrol. 2009 Jul; 24(7):1277-85. PMID: 19011906.
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    245. Ackert-Bicknell CL, Shockley KR, Horton LG, Lecka-Czernik B, Churchill GA, Rosen CJ. Strain-specific effects of rosiglitazone on bone mass, body composition, and serum insulin-like growth factor-I. Endocrinology. 2009 Mar; 150(3):1330-40. PMID: 18948404; PMCID: PMC2654751.
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    246. Mårtensson UE, Salehi SA, Windahl S, Gomez MF, Swärd K, Daszkiewicz-Nilsson J, Wendt A, Andersson N, Hellstrand P, Grände PO, Owman C, Rosen CJ, Adamo ML, Lundquist I, Rorsman P, Nilsson BO, Ohlsson C, Olde B, Leeb-Lundberg LM. Deletion of the G protein-coupled receptor 30 impairs glucose tolerance, reduces bone growth, increases blood pressure, and eliminates estradiol-stimulated insulin release in female mice. Endocrinology. 2009 Feb; 150(2):687-98. PMID: 18845638.
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    247. Garnero P, Bauer DC, Mareau E, Bilezikian JP, Greenspan SL, Rosen C, Black D. Effects of PTH and alendronate on type I collagen isomerization in postmenopausal women with osteoporosis: the PaTH study. J Bone Miner Res. 2008 Sep; 23(9):1442-8. PMID: 18442311; PMCID: PMC2683159.
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    248. Ishimori N, Stylianou IM, Korstanje R, Marion MA, Li R, Donahue LR, Rosen CJ, Beamer WG, Paigen B, Churchill GA. Quantitative trait loci for BMD in an SM/J by NZB/BlNJ intercross population and identification of Trps1 as a probable candidate gene. J Bone Miner Res. 2008 Sep; 23(9):1529-37. PMID: 18442308; NIHMSID: NIHMS77498.
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    250. Maddalozzo GF, Iwaniec UT, Turner RT, Rosen CJ, Widrick JJ. Whole-body vibration slows the acquisition of fat in mature female rats. Int J Obes (Lond). 2008 Sep; 32(9):1348-54. PMID: 18663370; NIHMSID: NIHMS77504.
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    251. Flood A, Mai V, Pfeiffer R, Kahle L, Rosen CJ, Lanza E, Schatzkin A. Serum concentrations of insulin-like growth factor and insulin-like growth factor binding protein 3 and recurrent colorectal adenomas. Cancer Epidemiol Biomarkers Prev. 2008 Jun; 17(6):1493-8. PMID: 18559566; NIHMSID: NIHMS59477.
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    253. Gladman DD, Schentag CT, Tom BD, Chandran V, Brockbank J, Rosen C, Farewell VT. Development and initial validation of a screening questionnaire for psoriatic arthritis: the Toronto Psoriatic Arthritis Screen (ToPAS). Ann Rheum Dis. 2009 Apr; 68(4):497-501. PMID: 18445625.
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    255. DeMambro VE, Clemmons DR, Horton LG, Bouxsein ML, Wood TL, Beamer WG, Canalis E, Rosen CJ. Gender-specific changes in bone turnover and skeletal architecture in igfbp-2-null mice. Endocrinology. 2008 May; 149(5):2051-61. PMID: 18276763; PMCID: PMC2329262.
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    259. Rosen CJ. Mouse models for understanding the growth hormone insulin-like growth factor-I axis. Horm Res. 2007; 68 Suppl 5:2-4. PMID: 18174693.
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    272. Yan J, Jiao Y, Li X, Jiao F, Beamer WG, Rosen CJ, Gu W. Evaluation of gene expression profiling in a mouse model of L-gulonolactone oxidase gene deficiency. Genet Mol Biol. 2007; 30(2):322-329. PMID: 18167513.
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    275. Recker R, Lips P, Felsenberg D, Lippuner K, Benhamou L, Hawkins F, Delmas PD, Rosen C, Emkey R, Salzmann G, He W, Santora AC. Alendronate with and without cholecalciferol for osteoporosis: results of a 15-week randomized controlled trial. Curr Med Res Opin. 2006 Sep; 22(9):1745-55. PMID: 16968578.
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    280. Rubin J, Fan X, Rahnert J, Sen B, Hsieh CL, Murphy TC, Nanes MS, Horton LG, Beamer WG, Rosen CJ. IGF-I secretion by prostate carcinoma cells does not alter tumor-bone cell interactions in vitro or in vivo. Prostate. 2006 Jun 1; 66(8):789-800. PMID: 16482567.
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    281. Delahunty KM, Shultz KL, Gronowicz GA, Koczon-Jaremko B, Adamo ML, Horton LG, Lorenzo J, Donahue LR, Ackert-Bicknell C, Kream BE, Beamer WG, Rosen CJ. Congenic mice provide in vivo evidence for a genetic locus that modulates serum insulin-like growth factor-I and bone acquisition. Endocrinology. 2006 Aug; 147(8):3915-23. PMID: 16675518.
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    295. Sheu YT, Zmuda JM, Cauley JA, Moffett SP, Rosen CJ, Ishwad C, Ferrell RE. Nuclear receptor coactivator-3 alleles are associated with serum bioavailable testosterone, insulin-like growth factor-1, and vertebral bone mass in men. J Clin Endocrinol Metab. 2006 Jan; 91(1):307-12. PMID: 16263829.
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    308. Horwitz MJ, Tedesco MB, Sereika SM, Syed MA, Garcia-Ocaña A, Bisello A, Hollis BW, Rosen CJ, Wysolmerski JJ, Dann P, Gundberg C, Stewart AF. Continuous PTH and PTHrP infusion causes suppression of bone formation and discordant effects on 1,25(OH)2 vitamin D. J Bone Miner Res. 2005 Oct; 20(10):1792-803. PMID: 16160737.
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    310. Mohan S, Kapoor A, Singgih A, Zhang Z, Taylor T, Yu H, Chadwick RB, Chung YS, Chung YS, Donahue LR, Rosen C, Crawford GC, Wergedal J, Baylink DJ. Spontaneous fractures in the mouse mutant sfx are caused by deletion of the gulonolactone oxidase gene, causing vitamin C deficiency. J Bone Miner Res. 2005 Sep; 20(9):1597-610. PMID: 16059632.
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    324. Miller PD, Schnitzer T, Emkey R, Orwoll E, Rosen C, Ettinger M, Vandormael K, Daifotis A. Weekly oral alendronic Acid in male osteoporosis. Clin Drug Investig. 2004; 24(6):333-41. PMID: 17516720.
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    325. Rubin J, Chung LW, Fan X, Zhu L, Murphy TC, Nanes MS, Rosen CJ. Prostate carcinoma cells that have resided in bone have an upregulated IGF-I axis. Prostate. 2004 Jan 1; 58(1):41-9. PMID: 14673951.
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    326. Rosen CJ, Black DM, Greenspan SL. Vignettes in osteoporosis: a road map to successful therapeutics. J Bone Miner Res. 2004 Jan; 19(1):3-10. PMID: 14753730.
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    330. Fan X, Roy E, Zhu L, Murphy TC, Ackert-Bicknell C, Hart CM, Rosen C, Nanes MS, Rubin J. Nitric oxide regulates receptor activator of nuclear factor-kappaB ligand and osteoprotegerin expression in bone marrow stromal cells. Endocrinology. 2004 Feb; 145(2):751-9. PMID: 14563699.
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    335. Donahue LR, Chang B, Mohan S, Miyakoshi N, Wergedal JE, Baylink DJ, Hawes NL, Rosen CJ, Ward-Bailey P, Zheng QY, Bronson RT, Johnson KR, Davisson MT. A missense mutation in the mouse Col2a1 gene causes spondyloepiphyseal dysplasia congenita, hearing loss, and retinoschisis. J Bone Miner Res. 2003 Sep; 18(9):1612-21. PMID: 12968670; NIHMSID: NIHMS197299.
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    337. Li Y, Iida K, O'Neil J, Zhang P, Li S, Frank A, Gabai A, Zambito F, Liang SH, Rosen CJ, Cavener DR. PERK eIF2alpha kinase regulates neonatal growth by controlling the expression of circulating insulin-like growth factor-I derived from the liver. Endocrinology. 2003 Aug; 144(8):3505-13. PMID: 12865332.
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    353. Rubin J, Ackert-Bicknell CL, Zhu L, Fan X, Murphy TC, Nanes MS, Marcus R, Holloway L, Beamer WG, Rosen CJ. IGF-I regulates osteoprotegerin (OPG) and receptor activator of nuclear factor-kappaB ligand in vitro and OPG in vivo. J Clin Endocrinol Metab. 2002 Sep; 87(9):4273-9. PMID: 12213884.
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    354. Bikle DD, Sakata T, Leary C, Elalieh H, Ginzinger D, Rosen CJ, Beamer W, Majumdar S, Halloran BP. Insulin-like growth factor I is required for the anabolic actions of parathyroid hormone on mouse bone. J Bone Miner Res. 2002 Sep; 17(9):1570-8. PMID: 12211426.
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    355. Cranney A, Guyatt G, Griffith L, Wells G, Tugwell P, Rosen C. Meta-analyses of therapies for postmenopausal osteoporosis. IX: Summary of meta-analyses of therapies for postmenopausal osteoporosis. Endocr Rev. 2002 Aug; 23(4):570-8. PMID: 12202472.
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    356. Gordon CM, Goodman E, Emans SJ, Grace E, Becker KA, Rosen CJ, Gundberg CM, Leboff MS. Physiologic regulators of bone turnover in young women with anorexia nervosa. J Pediatr. 2002 Jul; 141(1):64-70. PMID: 12091853.
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    357. Rosen CJ. Add-backs to prevent skeletal fragility: foresight or folly? Menopause. 2002 Jul-Aug; 9(4):224-6. PMID: 12082357.
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    358. Schoen RE, Schragin J, Weissfeld JL, Thaete FL, Evans RW, Rosen CJ, Kuller LH. Lack of association between adipose tissue distribution and IGF-1 and IGFBP-3 in men and women. Cancer Epidemiol Biomarkers Prev. 2002 Jun; 11(6):581-6. PMID: 12050100.
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    359. Pratipanawatr T, Pratipanawatr W, Rosen C, Berria R, Bajaj M, Cusi K, Mandarino L, Kashyap S, Belfort R, DeFronzo RA. Effect of IGF-I on FFA and glucose metabolism in control and type 2 diabetic subjects. Am J Physiol Endocrinol Metab. 2002 Jun; 282(6):E1360-8. PMID: 12006367.
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    360. Boonen S, Rosen C, Bouillon R, Sommer A, McKay M, Rosen D, Adams S, Broos P, Lenaerts J, Raus J, Vanderschueren D, Geusens P. Musculoskeletal effects of the recombinant human IGF-I/IGF binding protein-3 complex in osteoporotic patients with proximal femoral fracture: a double-blind, placebo-controlled pilot study. J Clin Endocrinol Metab. 2002 Apr; 87(4):1593-9. PMID: 11932288.
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    361. Bouxsein ML, Rosen CJ, Turner CH, Ackert CL, Shultz KL, Donahue LR, Churchill G, Adamo ML, Powell DR, Turner RT, Muller R, Beamer WG. Generation of a new congenic mouse strain to test the relationships among serum insulin-like growth factor I, bone mineral density, and skeletal morphology in vivo. J Bone Miner Res. 2002 Apr; 17(4):570-9. PMID: 11918215.
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    362. Beamer WG, Donahue LR, Rosen CJ. Genetics and bone. Using the mouse to understand man. J Musculoskelet Neuronal Interact. 2002 Mar; 2(3):225-31. PMID: 15758440.
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    363. Gu W, Li X, Lau KH, Edderkaoui B, Donahae LR, Rosen CJ, Beamer WG, Shultz KL, Srivastava A, Mohan S, Baylink DJ. Gene expression between a congenic strain that contains a quantitative trait locus of high bone density from CAST/EiJ and its wild-type strain C57BL/6J. Funct Integr Genomics. 2002 Apr; 1(6):375-86. PMID: 11957112.
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    364. Hayman SR, Drake WM, Kendler DL, Olszynski WP, Webber CE, Rosen CJ, Genant HK, Orwoll ES, Pickard LE, Adachi JD. North American male reference population for speed of sound in bone at multiple skeletal sites. J Clin Densitom. 2002; 5(1):63-71. PMID: 11940730.
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    365. Tuckerman K, Hofmaster P, Rosen CJ, Turi M. Bone density in ambulatory and immobile children. J Clin Densitom. 2002; 5(4):327-34. PMID: 12665632.
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    366. Bikle D, Majumdar S, Laib A, Powell-Braxton L, Rosen C, Beamer W, Nauman E, Leary C, Halloran B. The skeletal structure of insulin-like growth factor I-deficient mice. J Bone Miner Res. 2001 Dec; 16(12):2320-9. PMID: 11760848.
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    367. Chesnut CH, Rosen CJ. Reconsidering the effects of antiresorptive therapies in reducing osteoporotic fracture. J Bone Miner Res. 2001 Dec; 16(12):2163-72. PMID: 11760829.
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    368. Morton S, Rosen C, Larkin E, Tishler P, Aylor J, Redline S. Predictors of sleep-disordered breathing in children with a history of tonsillectomy and/or adenoidectomy. Sleep. 2001 Nov 1; 24(7):823-9. PMID: 11683485.
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    369. Beamer WG, Shultz KL, Donahue LR, Churchill GA, Sen S, Wergedal JR, Baylink DJ, Rosen CJ. Quantitative trait loci for femoral and lumbar vertebral bone mineral density in C57BL/6J and C3H/HeJ inbred strains of mice. J Bone Miner Res. 2001 Jul; 16(7):1195-206. PMID: 11450694.
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    370. Hennessey JV, Chromiak JA, DellaVentura S, Reinert SE, Puhl J, Kiel DP, Rosen CJ, Vandenburgh H, MacLean DB. Growth hormone administration and exercise effects on muscle fiber type and diameter in moderately frail older people. J Am Geriatr Soc. 2001 Jul; 49(7):852-8. PMID: 11527474.
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    371. Milne M, Quail JM, Rosen CJ, Baran DT. Insulin-like growth factor binding proteins in femoral and vertebral bone marrow stromal cells: expression and regulation by thyroid hormone and dexamethasone. J Cell Biochem. 2001 Mar 26; 81(2):229-40. PMID: 11241663.
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    372. Rosen CJ, Bilezikian JP. Clinical review 123: Anabolic therapy for osteoporosis. J Clin Endocrinol Metab. 2001 Mar; 86(3):957-64. PMID: 11238469.
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    373. Rosen CJ, Rackoff PJ. Emerging anabolic treatments for osteoporosis. Rheum Dis Clin North Am. 2001 Feb; 27(1):215-33, viii. PMID: 11285997.
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    374. Turner CH, Hsieh YF, Müller R, Bouxsein ML, Rosen CJ, McCrann ME, Donahue LR, Beamer WG. Variation in bone biomechanical properties, microstructure, and density in BXH recombinant inbred mice. J Bone Miner Res. 2001 Feb; 16(2):206-13. PMID: 11204420.
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    375. Richman C, Kutilek S, Miyakoshi N, Srivastava AK, Beamer WG, Donahue LR, Rosen CJ, Wergedal JE, Baylink DJ, Mohan S. Postnatal and pubertal skeletal changes contribute predominantly to the differences in peak bone density between C3H/HeJ and C57BL/6J mice. J Bone Miner Res. 2001 Feb; 16(2):386-97. PMID: 11204439.
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    376. Rosen CJ. Treatment of postmenopausal osteoporosis: an evidence-based approach. Rev Endocr Metab Disord. 2001 Jan; 2(1):35-43. PMID: 11704978.
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    377. Rosen CJ, Beamer WG, Donahue LR. Defining the genetics of osteoporosis: using the mouse to understand man. Osteoporos Int. 2001; 12(10):803-10. PMID: 11716182.
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    378. Drake WM, McClung M, Njeh CF, Genant HK, Rosen C, Watts N, Kendler DL. Multisite bone ultrasound measurement on North American female reference population. J Clin Densitom. 2001; 4(3):239-48. PMID: 11740066.
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    379. Beamer WG, Rosen CJ, Bronson RT, Gu W, Donahue LR, Baylink DJ, Richardson CC, Crawford GC, Barker JE. Spontaneous fracture (sfx): a mouse genetic model of defective peripubertal bone formation. Bone. 2000 Nov; 27(5):619-26. PMID: 11062347.
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    380. Sreekumar R, Gonzalez-Koch A, Maor-Kendler Y, Batts K, Moreno-Luna L, Poterucha J, Burgart L, Wiesner R, Kremers W, Rosen C, Charlton MR. Early identification of recipients with progressive histologic recurrence of hepatitis C after liver transplantation. Hepatology. 2000 Nov; 32(5):1125-30. PMID: 11050065.
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    381. Snow CM, Rosen CJ, Robinson TL. Serum IGF-I is higher in gymnasts than runners and predicts bone and lean mass. Med Sci Sports Exerc. 2000 Nov; 32(11):1902-7. PMID: 11079520.
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    382. Rosen CJ, Churchill GA, Donahue LR, Shultz KL, Burgess JK, Powell DR, Ackert C, Beamer WG. Mapping quantitative trait loci for serum insulin-like growth factor-1 levels in mice. Bone. 2000 Oct; 27(4):521-8. PMID: 11033447.
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    383. Wallach S, Cohen S, Reid DM, Hughes RA, Hosking DJ, Laan RF, Doherty SM, Maricic M, Rosen C, Brown J, Barton I, Chines AA. Effects of risedronate treatment on bone density and vertebral fracture in patients on corticosteroid therapy. Calcif Tissue Int. 2000 Oct; 67(4):277-85. PMID: 11000340.
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    384. Rosen CJ. Pathophysiology of osteoporosis. Clin Lab Med. 2000 Sep; 20(3):455-68. PMID: 10986615.
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    385. Rosen CJ. IGF-I and osteoporosis. Clin Lab Med. 2000 Sep; 20(3):591-602. PMID: 10986623.
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    386. Kurland ES, Cosman F, McMahon DJ, Rosen CJ, Lindsay R, Bilezikian JP. Parathyroid hormone as a therapy for idiopathic osteoporosis in men: effects on bone mineral density and bone markers. J Clin Endocrinol Metab. 2000 Sep; 85(9):3069-76. PMID: 10999788.
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    387. Kodama Y, Miyakoshi N, Linkhart TA, Wergedal J, Srivastava A, Beamer W, Donahue LR, Rosen C, Baylink DJ, Farley J. Effects of dietary calcium depletion and repletion on dynamic determinants of tibial bone volume in two inbred strains of mice. Bone. 2000 Sep; 27(3):445-52. PMID: 10962358.
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    388. Goodman-Gruen D, Barrett-Connor E, Rosen C. IGF-1 and ischemic heart disease in older people. J Am Geriatr Soc. 2000 Jul; 48(7):860-1. PMID: 10894338.
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    389. Zhao G, Monier-Faugere MC, Langub MC, Geng Z, Nakayama T, Pike JW, Chernausek SD, Rosen CJ, Donahue LR, Malluche HH, Fagin JA, Clemens TL. Targeted overexpression of insulin-like growth factor I to osteoblasts of transgenic mice: increased trabecular bone volume without increased osteoblast proliferation. Endocrinology. 2000 Jul; 141(7):2674-82. PMID: 10875273.
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    390. Rosen CJ. Pathogenesis of osteoporosis. Baillieres Best Pract Res Clin Endocrinol Metab. 2000 Jun; 14(2):181-93. PMID: 11035901.
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    391. Turner CH, Hsieh YF, Müller R, Bouxsein ML, Baylink DJ, Rosen CJ, Grynpas MD, Donahue LR, Beamer WG. Genetic regulation of cortical and trabecular bone strength and microstructure in inbred strains of mice. J Bone Miner Res. 2000 Jun; 15(6):1126-31. PMID: 10841181.
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    392. Rittmaster RS, Bolognese M, Ettinger MP, Hanley DA, Hodsman AB, Kendler DL, Rosen CJ. Enhancement of bone mass in osteoporotic women with parathyroid hormone followed by alendronate. J Clin Endocrinol Metab. 2000 Jun; 85(6):2129-34. PMID: 10852440.
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    393. Haden ST, Glowacki J, Hurwitz S, Rosen C, LeBoff MS. Effects of age on serum dehydroepiandrosterone sulfate, IGF-I, and IL-6 levels in women. Calcif Tissue Int. 2000 Jun; 66(6):414-8. PMID: 10821876.
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    394. Greenspan SL, Harris ST, Bone H, Miller PD, Orwoll ES, Watts NB, Rosen CJ. Bisphosphonates: safety and efficacy in the treatment and prevention of osteoporosis. Am Fam Physician. 2000 May 1; 61(9):2731-6. PMID: 10821153.
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    395. Berman S, Miller AC, Rosen C, Bicchieri S. Assessment training and team functioning for treating children with disabilities. Arch Phys Med Rehabil. 2000 May; 81(5):628-33. PMID: 10807104.
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    396. Rosen CJ. Growth hormone and aging. Endocrine. 2000 Apr; 12(2):197-201. PMID: 10905380.
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    397. Toth MJ, Tchernof A, Rosen CJ, Matthews DE, Poehlman ET. Regulation of protein metabolism in middle-aged, premenopausal women: roles of adiposity and estradiol. J Clin Endocrinol Metab. 2000 Apr; 85(4):1382-7. PMID: 10770170.
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    398. Beamer WG, Donahue LR, Rosen CJ. Insulin-like growth factor I and bone: from mouse to man. Growth Horm IGF Res. 2000 Apr; 10 Suppl B:S103-5. PMID: 10984263.
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    399. Torigoi E, Bennani-Baiti IM, Rosen C, Gonzalez K, Morcillo P, Ptashne M, Dorsett D. Chip interacts with diverse homeodomain proteins and potentiates bicoid activity in vivo. Proc Natl Acad Sci U S A. 2000 Mar 14; 97(6):2686-91. PMID: 10688916; PMCID: PMC15990.
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    400. Rosen CJ. Fluoride and fractures: an ecological fallacy. Lancet. 2000 Jan 22; 355(9200):247-8. PMID: 10675067.
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    401. Rosen CJ. Issues facing bone densitometry in the new century: reflections from the National Institutes of Health Consensus Development Conference on Osteoporosis. J Clin Densitom. 2000; 3(3):211-3. PMID: 11090227.
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    402. Rosen CJ, Bilezikian JP. Perplexing polymorphisms: D(i)ps, Sn(i)ps, and trips. J Clin Endocrinol Metab. 1999 Dec; 84(12):4465-6. PMID: 10599703.
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    403. Beamer WG, Shultz KL, Churchill GA, Frankel WN, Baylink DJ, Rosen CJ, Donahue LR. Quantitative trait loci for bone density in C57BL/6J and CAST/EiJ inbred mice. Mamm Genome. 1999 Nov; 10(11):1043-9. PMID: 10556421.
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    404. Sheng MH, Baylink DJ, Beamer WG, Donahue LR, Rosen CJ, Lau KH, Wergedal JE. Histomorphometric studies show that bone formation and bone mineral apposition rates are greater in C3H/HeJ (high-density) than C57BL/6J (low-density) mice during growth. Bone. 1999 Oct; 25(4):421-9. PMID: 10511108.
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    405. Sites CK, Tischler MD, Rosen CJ, O'Connell M, Niggel J, Ashikaga T. Effect of short-term medroxyprogesterone acetate on left ventricular mass: role of insulin-like growth factor-1. Metabolism. 1999 Oct; 48(10):1328-31. PMID: 10535399.
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    406. Heaney RP, McCarron DA, Dawson-Hughes B, Oparil S, Berga SL, Stern JS, Barr SI, Rosen CJ. Dietary changes favorably affect bone remodeling in older adults. J Am Diet Assoc. 1999 Oct; 99(10):1228-33. PMID: 10524386.
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    407. Rosen CJ. Serum insulin-like growth factors and insulin-like growth factor-binding proteins: clinical implications. Clin Chem. 1999 Aug; 45(8 Pt 2):1384-90. PMID: 10430822.
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    408. Kodama Y, Dimai HP, Wergedal J, Sheng M, Malpe R, Kutilek S, Beamer W, Donahue LR, Rosen C, Baylink DJ, Farley J. Cortical tibial bone volume in two strains of mice: effects of sciatic neurectomy and genetic regulation of bone response to mechanical loading. Bone. 1999 Aug; 25(2):183-90. PMID: 10456383.
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    409. Snyder PJ, Peachey H, Hannoush P, Berlin JA, Loh L, Lenrow DA, Holmes JH, Dlewati A, Santanna J, Rosen CJ, Strom BL. Effect of testosterone treatment on body composition and muscle strength in men over 65 years of age. J Clin Endocrinol Metab. 1999 Aug; 84(8):2647-53. PMID: 10443654.
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    410. Goldfrank L, Henneman PL, Ling LJ, Prescott JE, Rosen C, Sama A. Emergency center categorization standards. Acad Emerg Med. 1999 Jun; 6(6):638-55. PMID: 10386683.
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    411. Kleerekoper M, Deftos L, Khosla S, Marcus R, Matrici M, McClung M, Rosen C, Shane E. Osteology: further debate. J Bone Miner Res. 1999 Jun; 14(6):1017. PMID: 10352128.
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    412. Niu T, Chen C, Cordell H, Yang J, Wang B, Wang Z, Fang Z, Schork NJ, Rosen CJ, Xu X. A genome-wide scan for loci linked to forearm bone mineral density. Hum Genet. 1999 Mar; 104(3):226-33. PMID: 10323246.
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    413. Rosen CJ. Images in densitometry: cervical osteoporosis. J Clin Densitom. 1999; 2(1):55-7. PMID: 23547314.
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    414. Linkhart TA, Linkhart SG, Kodama Y, Farley JR, Dimai HP, Wright KR, Wergedal JE, Sheng M, Beamer WG, Donahue LR, Rosen CJ, Baylink DJ. Osteoclast formation in bone marrow cultures from two inbred strains of mice with different bone densities. J Bone Miner Res. 1999 Jan; 14(1):39-46. PMID: 9893064.
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    415. Rosen CJ. "Through the valley of dry bones". J Clin Densitom. 1999; 2(1):3-4. PMID: 23547306.
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    416. Cook DJ, Guyatt GH, Adachi JD, Epstein RS, Juniper EF, Austin PA, Clifton J, Rosen CJ, Kessenich CR, Stock JL, Overdorf J, Miller PD, Erickson AL, McCLung MR, McClung BL, Griffith LE, Ioannidis G. Development and validation of the mini-osteoporosis quality of life questionnaire (OQLQ) in osteoporotic women with back pain due to vertebral fractures. Osteoporosis Quality of Life Study Group. Osteoporos Int. 1999; 10(3):207-13. PMID: 10525712.
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    417. Rosen CJ. Conflict of interest: explicit rules! J Clin Densitom. 1999; 2(3):209-10. PMID: 10548815.
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    418. Jiang Y, Zhao J, Rosen C, Geusens P, Genant HK. Perspectives on bone mechanical properties and adaptive response to mechanical challenge. J Clin Densitom. 1999; 2(4):423-33. PMID: 10677796.
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    419. Langlois JA, Rosen CJ, Visser M, Hannan MT, Harris T, Wilson PW, Kiel DP. Association between insulin-like growth factor I and bone mineral density in older women and men: the Framingham Heart Study. J Clin Endocrinol Metab. 1998 Dec; 83(12):4257-62. PMID: 9851760.
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    420. Rosen CJ, Rackoff PJ. Ultrasound proves clinical usefulness in osteoporosis. Diagn Imaging (San Franc). 1998 Nov; Suppl Bone Mass:11-5. PMID: 10345139.
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    421. Storm D, Eslin R, Porter ES, Musgrave K, Vereault D, Patton C, Kessenich C, Mohan S, Chen T, Holick MF, Rosen CJ. Calcium supplementation prevents seasonal bone loss and changes in biochemical markers of bone turnover in elderly New England women: a randomized placebo-controlled trial. J Clin Endocrinol Metab. 1998 Nov; 83(11):3817-25. PMID: 9814452.
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    422. Salzer JL, Lovejoy L, Linder MC, Rosen C. Ran-2, a glial lineage marker, is a GPI-anchored form of ceruloplasmin. J Neurosci Res. 1998 Oct 15; 54(2):147-57. PMID: 9788274.
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    423. Rosen CJ, Tenenhouse A. Biochemical markers of bone turnover. A look at laboratory tests that reflect bone status. Postgrad Med. 1998 Oct; 104(4):101-2, 107-10, 113-4. PMID: 9793558.
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    424. Rosen CJ, Donahue LR. Insulin-like growth factors and bone: the osteoporosis connection revisited. Proc Soc Exp Biol Med. 1998 Oct; 219(1):1-7. PMID: 9751217.
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    425. Patton CL, Millard PS, Kessenich CR, Storm D, Kinnicutt E, Rosen CJ. Screening calcaneal ultrasound and risk factors for osteoporosis among lesbians and heterosexual women. J Womens Health. 1998 Sep; 7(7):909-15. PMID: 9785317.
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    426. Kurland ES, Chan FK, Rosen CJ, Bilezikian JP. Normal growth hormone secretory reserve in men with idiopathic osteoporosis and reduced circulating levels of insulin-like growth factor-I. J Clin Endocrinol Metab. 1998 Jul; 83(7):2576-9. PMID: 9661647.
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    427. Rosen CJ, Kurland ES, Vereault D, Adler RA, Rackoff PJ, Craig WY, Witte S, Rogers J, Bilezikian JP. Association between serum insulin growth factor-I (IGF-I) and a simple sequence repeat in IGF-I gene: implications for genetic studies of bone mineral density. J Clin Endocrinol Metab. 1998 Jul; 83(7):2286-90. PMID: 9661596.
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    428. Kiel DP, Puhl J, Rosen CJ, Berg K, Murphy JB, MacLean DB. Lack of an association between insulin-like growth factor-I and body composition, muscle strength, physical performance or self-reported mobility among older persons with functional limitations. J Am Geriatr Soc. 1998 Jul; 46(7):822-8. PMID: 9670867.
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    429. Devine A, Rosen C, Mohan S, Baylink D, Prince RL. Effects of zinc and other nutritional factors on insulin-like growth factor I and insulin-like growth factor binding proteins in postmenopausal women. Am J Clin Nutr. 1998 Jul; 68(1):200-6. PMID: 9665115.
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    430. Rackoff PJ, Rosen CJ. Pathogenesis and treatment of glucocorticoid-induced osteoporosis. Drugs Aging. 1998 Jun; 12(6):477-84. PMID: 9638395.
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    431. Roubenoff R, Rall LC, Veldhuis JD, Kehayias JJ, Rosen C, Nicolson M, Lundgren N, Reichlin S. The relationship between growth hormone kinetics and sarcopenia in postmenopausal women: the role of fat mass and leptin. J Clin Endocrinol Metab. 1998 May; 83(5):1502-6. PMID: 9589646.
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    432. Rosen C, Dorsett D, Jack J. A proline-rich region in the Zeste protein essential for transvection and white repression by Zeste. Genetics. 1998 Apr; 148(4):1865-74. PMID: 9560400; PMCID: PMC1460061.
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    433. Rosen C, Miller AC, Pit-ten Cate IM, Bicchieri S, Gordon RM, Daniele R. Team approaches to treating children with disabilities: a comparison. Arch Phys Med Rehabil. 1998 Apr; 79(4):430-4. PMID: 9552110.
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    434. Rosen CJ. Pre-emptive bone strikes in prevention of osteoporosis. Lancet. 1998 Mar 28; 351(9107):927-8. PMID: 9734936.
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    435. Kessenich CR, Guyatt GH, Rosen CJ. Health-related quality of life and participation in osteoporosis clinical trials. Calcif Tissue Int. 1998 Mar; 62(3):189-92. PMID: 9501949.
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    436. Dimai HP, Linkhart TA, Linkhart SG, Donahue LR, Beamer WG, Rosen CJ, Farley JR, Baylink DJ. Alkaline phosphatase levels and osteoprogenitor cell numbers suggest bone formation may contribute to peak bone density differences between two inbred strains of mice. Bone. 1998 Mar; 22(3):211-6. PMID: 9514213.
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    437. Klein GL, Wolf SE, Langman CB, Rosen CJ, Mohan S, Keenan BS, Matin S, Steffen C, Nicolai M, Sailer DE, Herndon DN. Effects of therapy with recombinant human growth hormone on insulin-like growth factor system components and serum levels of biochemical markers of bone formation in children after severe burn injury. J Clin Endocrinol Metab. 1998 Jan; 83(1):21-4. PMID: 9435411.
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    438. Rackoff PJ, Rosen CJ. Peripheral bone mass measurements: current and future perspectives on quantitative ultrasound and peripheral DXA. J Clin Densitom. 1998; 1(3):287-94. PMID: 15304901.
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    439. Rosen CJ, Glowacki J, Craig W. Sex steroids, the insulin-like growth factor regulatory system, and aging: implications for the management of older postmenopausal women. J Nutr Health Aging. 1998; 2(1):39-44. PMID: 10995078.
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    440. Sataloff RT, Rosen C, Hawkshaw M. Occult mucosal bridge of the vocal fold. Ear Nose Throat J. 1997 Dec; 76(12):850. PMID: 9431771.
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    441. Rosen CJ, Conover C. Growth hormone/insulin-like growth factor-I axis in aging: a summary of a National Institutes of Aging-Sponsored Symposium. J Clin Endocrinol Metab. 1997 Dec; 82(12):3919-22. PMID: 9398687.
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    442. Rosen CJ. A tale of two worlds in prescribing etidronate for osteoporosis. Lancet. 1997 Nov 8; 350(9088):1340. PMID: 9365446.
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    443. Morcillo P, Rosen C, Baylies MK, Dorsett D. Chip, a widely expressed chromosomal protein required for segmentation and activity of a remote wing margin enhancer in Drosophila. Genes Dev. 1997 Oct 15; 11(20):2729-40. PMID: 9334334; PMCID: PMC316608.
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    444. Rosen C, Bilezikian JP. Evolving toward a new paradigm for prevention of osteoporosis--the time is upon us. J Clin Endocrinol Metab. 1997 Sep; 82(9):2782-3. PMID: 9284695.
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    445. Kurland ES, Rosen CJ, Cosman F, McMahon D, Chan F, Shane E, Lindsay R, Dempster D, Bilezikian JP. Insulin-like growth factor-I in men with idiopathic osteoporosis. J Clin Endocrinol Metab. 1997 Sep; 82(9):2799-805. PMID: 9284699.
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    446. Rosen CJ. Insulin-like growth factor-I and parathyroid hormone: potential new therapeutic agents for the treatment of osteoporosis. Expert Opin Investig Drugs. 1997 Sep; 6(9):1193-8. PMID: 15991894.
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    447. Rosen CJ, Dimai HP, Vereault D, Donahue LR, Beamer WG, Farley J, Linkhart S, Linkhart T, Mohan S, Baylink DJ. Circulating and skeletal insulin-like growth factor-I (IGF-I) concentrations in two inbred strains of mice with different bone mineral densities. Bone. 1997 Sep; 21(3):217-23. PMID: 9276086.
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    448. Rabban J, Adler J, Rosen C, Blair J, Sheridan R. Electrical injury from subway third rails: serious injury associated with intermediate voltage contact. Burns. 1997 Sep; 23(6):515-8. PMID: 9429035.
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    449. Rosen CJ, Verault D, Steffens C, Cheleuitte D, Glowacki J. Effects of age and estrogen status on the skeletal IGF regulatory system. Studies with human marrow. Endocrine. 1997 Aug; 7(1):77-80. PMID: 9449037.
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    450. Rosen CJ. Growth hormone, IGF-I, and the elderly. Clues to potential therapeutic interventions. Endocrine. 1997 Aug; 7(1):39-40. PMID: 9449029.
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    451. Rosen CJ. Endocrine disorders and osteoporosis. Curr Opin Rheumatol. 1997 Jul; 9(4):355-61. PMID: 9229183.
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    452. Rosen CJ, Chesnut CH, Mallinak NJ. The predictive value of biochemical markers of bone turnover for bone mineral density in early postmenopausal women treated with hormone replacement or calcium supplementation. J Clin Endocrinol Metab. 1997 Jun; 82(6):1904-10. PMID: 9177404.
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    453. Rosen CJ, Kessenich CR. The pathophysiology and treatment of postmenopausal osteoporosis. An evidence-based approach to estrogen replacement therapy. Endocrinol Metab Clin North Am. 1997 Jun; 26(2):295-311. PMID: 9193885.
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    454. Poehlman ET, Toth MJ, Goran MI, Carpenter WH, Newhouse P, Rosen CJ. Daily energy expenditure in free-living non-institutionalized Alzheimer's patients: a doubly labeled water study. Neurology. 1997 Apr; 48(4):997-1002. PMID: 9109890.
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    455. Poehlman ET, Toth MJ, Ades PA, Rosen CJ. Menopause-associated changes in plasma lipids, insulin-like growth factor I and blood pressure: a longitudinal study. Eur J Clin Invest. 1997 Apr; 27(4):322-6. PMID: 9134381.
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    456. Rogers J, Mahaney MC, Beamer WG, Donahue LR, Rosen CJ. Beyond one gene-one disease: alternative strategies for deciphering genetic determinants of osteoporosis. Calcif Tissue Int. 1997 Mar; 60(3):225-8. PMID: 9069155.
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    457. Millard PS, Rosen CJ, Johnson KH. Osteoporotic vertebral fractures in postmenopausal women. Am Fam Physician. 1997 Mar; 55(4):1315-22. PMID: 9092292.
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    458. Ji H, Liu YE, Jia T, Wang M, Liu J, Xiao G, Joseph BK, Rosen C, Shi YE. Identification of a breast cancer-specific gene, BCSG1, by direct differential cDNA sequencing. Cancer Res. 1997 Feb 15; 57(4):759-64. PMID: 9044857.
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    459. Zeng Z, Parmelee D, Hyaw H, Coleman TA, Su K, Zhang J, Gentz R, Ruben S, Rosen C, Li Y. Cloning and characterization of a novel human DNase. Biochem Biophys Res Commun. 1997 Feb 13; 231(2):499-504. PMID: 9070308.
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    460. Chesnut CH, Bell NH, Clark GS, Drinkwater BL, English SC, Johnson CC, Notelovitz M, Rosen C, Cain DF, Flessland KA, Mallinak NJ. Hormone replacement therapy in postmenopausal women: urinary N-telopeptide of type I collagen monitors therapeutic effect and predicts response of bone mineral density. Am J Med. 1997 Jan; 102(1):29-37. PMID: 9209198.
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    461. Bryant NJ, Woodson GE, Kaufman K, Rosen C, Hengesteg A, Chen N, Yeung D. Human posterior cricoarytenoid muscle compartments. Anatomy and mechanics. Arch Otolaryngol Head Neck Surg. 1996 Dec; 122(12):1331-6. PMID: 8956745.
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    462. Morcillo P, Rosen C, Dorsett D. Genes regulating the remote wing margin enhancer in the Drosophila cut locus. Genetics. 1996 Nov; 144(3):1143-54. PMID: 8913756; PMCID: PMC1207607.
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    463. Rall LC, Rosen CJ, Dolnikowski G, Hartman WJ, Lundgren N, Abad LW, Dinarello CA, Roubenoff R. Protein metabolism in rheumatoid arthritis and aging. Effects of muscle strength training and tumor necrosis factor alpha. Arthritis Rheum. 1996 Jul; 39(7):1115-24. PMID: 8670319.
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    464. Kim J, Shen B, Rosen C, Dorsett D. The DNA-binding and enhancer-blocking domains of the Drosophila suppressor of Hairy-wing protein. Mol Cell Biol. 1996 Jul; 16(7):3381-92. PMID: 8668153; PMCID: PMC231332.
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    465. Miller PD, Bonnick SL, Rosen CJ, Altman RD, Avioli LV, Dequeker J, Felsenberg D, Genant HK, Gennari C, Harper KD, Hodsman AB, Kleerekoper M, Mautalen CA, McClung MR, Meunier PJ, Nelson DA, Peel NF, Raisz LG, Recker RR, Utian WH, Wasnich RD, Watts NB. Clinical utility of bone mass measurements in adults: consensus of an international panel. The Society for Clinical Densitometry. Semin Arthritis Rheum. 1996 Jun; 25(6):361-72. PMID: 8792508.
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    466. Prior RL, Crim MC, Castaneda C, Lammi-Keefe C, Dawson-Hughes B, Rosen CJ, Spindler AA. Conditions altering plasma concentrations of urea cycle and other amino acids in elderly human subjects. J Am Coll Nutr. 1996 Jun; 15(3):237-47. PMID: 8935439.
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    467. Beamer WG, Donahue LR, Rosen CJ, Baylink DJ. Genetic variability in adult bone density among inbred strains of mice. Bone. 1996 May; 18(5):397-403. PMID: 8739896.
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    468. Kessenich CR, Rosen CJ. Vitamin D and bone status in elderly women. Orthop Nurs. 1996 May-Jun; 15(3):67-71. PMID: 8788649.
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    469. Kim N, Kim J, Park D, Rosen C, Dorsett D, Yim J. Structure and expression of wild-type and suppressible alleles of the Drosophila purple gene. Genetics. 1996 Apr; 142(4):1157-68. PMID: 8846895; PMCID: PMC1207115.
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    470. Miller PD, Bonnick SL, Rosen CJ. Consensus of an international panel on the clinical utility of bone mass measurements in the detection of low bone mass in the adult population. Calcif Tissue Int. 1996 Apr; 58(4):207-14. PMID: 8661948.
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    471. Plymate SR, Rosen CJ, Paulsen CA, Ware JL, Chen J, Vessella RE, Birnbaum RS. Proteolysis of insulin-like growth factor-binding protein-3 in the male reproductive tract. J Clin Endocrinol Metab. 1996 Feb; 81(2):618-24. PMID: 8636278.
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    472. Miller PD, Bonnick SL, Rosen C. Guidelines for the clinical utilization of bone mass measurement in the adult population. Society for Clinical Densitometry. Calcif Tissue Int. 1995 Oct; 57(4):251-2. PMID: 8673860.
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    473. Rosen CJ, Donahue LR. Insulinlike growth factors: Potential therapeutic options for osteoporosis. Trends Endocrinol Metab. 1995 Sep; 6(7):235-40. PMID: 18406706.
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    474. Rosen HN, Tollin S, Balena R, Middlebrooks VL, Beamer WG, Donohue LR, Rosen C, Turner A, Holick M, Greenspan SL. Differentiating between orchiectomized rats and controls using measurements of trabecular bone density: a comparison among DXA, histomorphometry, and peripheral quantitative computerized tomography. Calcif Tissue Int. 1995 Jul; 57(1):35-9. PMID: 7671163.
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    475. Bell C, Dubose R, Seashore J, Touloukian R, Rosen C, Oh TH, Hughes CW, Mooney S, O'Connor TZ. Infant apnea detection after herniorrhaphy. J Clin Anesth. 1995 May; 7(3):219-23. PMID: 7669312.
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    476. Rosen CJ. Growth hormone, insulin-like growth factors, and the senescent skeleton: Ponce de Leon's Fountain revisited? J Cell Biochem. 1994 Nov; 56(3):348-56. PMID: 7876328.
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    477. Poehlman ET, Rosen CJ, Copeland KC. The influence of endurance training on insulin-like growth factor-1 in older individuals. Metabolism. 1994 Nov; 43(11):1401-5. PMID: 7526125.
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    478. Shewmon DA, Stock JL, Rosen CJ, Heiniluoma KM, Hogue MM, Morrison A, Doyle EM, Ukena T, Weale V, Baker S. Tamoxifen and estrogen lower circulating lipoprotein(a) concentrations in healthy postmenopausal women. Arterioscler Thromb. 1994 Oct; 14(10):1586-93. PMID: 7522547.
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    479. Bagley J, Dillon PJ, Rosen C, Robinson J, Sodroski J, Marasco WA. Structural characterization of broadly neutralizing human monoclonal antibodies against the CD4 binding site of HIV-1 gp120. Mol Immunol. 1994 Oct; 31(15):1149-60. PMID: 7935503.
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    480. Rosen CJ, Holick MF, Millard PS. Premature graying of hair is a risk marker for osteopenia. J Clin Endocrinol Metab. 1994 Sep; 79(3):854-7. PMID: 8077373.
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    481. Adler RA, Rosen CJ. Glucocorticoids and osteoporosis. Endocrinol Metab Clin North Am. 1994 Sep; 23(3):641-54. PMID: 7805660.
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    482. Coulston AM, Rosen C. American health care reform: implications for medical nutrition therapy. Am J Clin Nutr. 1994 Jun; 59(6):1275-6. PMID: 8198050.
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    483. Rosen CJ, Donahue LR, Hunter SJ. Insulin-like growth factors and bone: the osteoporosis connection. Proc Soc Exp Biol Med. 1994 Jun; 206(2):83-102. PMID: 8208742.
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    484. Rosen CJ. Health care reform in the United States: implications for the management of patients with metabolic bone diseases. J Bone Miner Res. 1994 May; 9(5):595-8. PMID: 8053386.
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    485. Rosen CJ, Morrison A, Zhou H, Storm D, Hunter SJ, Musgrave K, Chen T, Wei W, Holick MF. Elderly women in northern New England exhibit seasonal changes in bone mineral density and calciotropic hormones. Bone Miner. 1994 May; 25(2):83-92. PMID: 8086854.
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    486. Gordon C, McGurk G, Dillon P, Rosen C, Hastie ND. Defective mitosis due to a mutation in the gene for a fission yeast 26S protease subunit. Nature. 1993 Nov 25; 366(6453):355-7. PMID: 8247131.
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    487. Scharla SH, Strong DD, Rosen C, Mohan S, Holick M, Baylink DJ, Linkhart TA. 1,25-Dihydroxyvitamin D3 increases secretion of insulin-like growth factor binding protein-4 (IGFBP-4) by human osteoblast-like cells in vitro and elevates IGFBP-4 serum levels in vivo. J Clin Endocrinol Metab. 1993 Nov; 77(5):1190-7. PMID: 7521341.
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    488. Hobbs CJ, Plymate SR, Rosen CJ, Adler RA. Testosterone administration increases insulin-like growth factor-I levels in normal men. J Clin Endocrinol Metab. 1993 Sep; 77(3):776-9. PMID: 7690364.
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    489. Bing-You RG, Denis MC, Rosen CJ. Low bone mineral density in adults with previous hypothalamic-pituitary tumors: correlations with serum growth hormone responses to GH-releasing hormone, insulin-like growth factor I, and IGF binding protein 3. Calcif Tissue Int. 1993 Mar; 52(3):183-7. PMID: 7683247.
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    490. Rosen CJ, Adler RA. Longitudinal changes in lumbar bone density among thyrotoxic patients after attainment of euthyroidism. J Clin Endocrinol Metab. 1992 Dec; 75(6):1531-4. PMID: 1464660.
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    491. Rosen C, Segal H, Hartz CE, Mroz F, Carlton E. Primary hyperparathyroidism in an elderly patient with multiple myeloma. J Am Geriatr Soc. 1992 Jul; 40(7):703-5. PMID: 1318890.
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    492. Garland DE, Stewart CA, Adkins RH, Hu SS, Rosen C, Liotta FJ, Weinstein DA. Osteoporosis after spinal cord injury. J Orthop Res. 1992 May; 10(3):371-8. PMID: 1569500.
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    493. Rosen C, Donahue LR, Hunter S, Holick M, Kavookjian H, Kirschenbaum A, Mohan S, Baylink DJ. The 24/25-kDa serum insulin-like growth factor-binding protein is increased in elderly women with hip and spine fractures. J Clin Endocrinol Metab. 1992 Jan; 74(1):24-7. PMID: 1370164.
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    494. Wahlstrom HE, Cooper J, Gores G, Rosen C, Wiesner R, Krom RA. Survival after liver transplantation in diabetics. Transplant Proc. 1991 Feb; 23(1 Pt 2):1565-6. PMID: 1989292.
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    495. Sanchez-Urdazpal L, Sterioff S, Janes C, Schwerman L, Rosen C, Krom RA. Increased bile duct complications in ABO incompatible liver transplant recipients. Transplant Proc. 1991 Feb; 23(1 Pt 2):1440-1. PMID: 1989259.
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    496. McEntee G, Wiesner RH, Rosen C, Cooper J, Wahlstrom E. A comparative study of patients undergoing liver transplantation for primary sclerosing cholangitis and primary biliary cirrhosis. Transplant Proc. 1991 Feb; 23(1 Pt 2):1563-4. PMID: 1989291.
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    497. Hunter SJ, Rosen CJ, Gay CV. In vitro resorptive activity of isolated chick osteoclasts: effects of carbonic anhydrase inhibition. J Bone Miner Res. 1991 Jan; 6(1):61-6. PMID: 2048433.
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    498. Donahue LR, Hunter SJ, Sherblom AP, Rosen C. Age-related changes in serum insulin-like growth factor-binding proteins in women. J Clin Endocrinol Metab. 1990 Sep; 71(3):575-9. PMID: 1697597.
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    499. Rosen CJ, Usiskin K, Owens M, Barlascini CO, Belsky M, Adler RA. T lymphocyte surface antigen markers in osteoporosis. J Bone Miner Res. 1990 Aug; 5(8):851-5. PMID: 2239369.
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    500. Davee AM, Rosen CJ, Adler RA. Exercise patterns and trabecular bone density in college women. J Bone Miner Res. 1990 Mar; 5(3):245-50. PMID: 2333783.
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    501. Markovitz DM, Kenney S, Kamine J, Smith MS, Davis M, Huang ES, Rosen C, Pagano JS. Disparate effects of two herpesvirus [corrected] immediate-early gene trans-activators on the HIV-1 LTR. Virology. 1989 Dec; 173(2):750-4. PMID: 2556854.
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    502. Musgrave KO, Giambalvo L, Leclerc HL, Cook RA, Rosen CJ. Validation of a quantitative food frequency questionnaire for rapid assessment of dietary calcium intake. J Am Diet Assoc. 1989 Oct; 89(10):1484-8. PMID: 2794308.
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    503. Rogers G, Taylor C, Austin JC, Rosen C. A pharyngostomy technique for chronic oral dosing of rabbits. Lab Anim Sci. 1988 Oct; 38(5):619-20. PMID: 3193760.
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    504. Walker BD, Kowalski M, Goh WC, Kozarsky K, Krieger M, Rosen C, Rohrschneider L, Haseltine WA, Sodroski J. Inhibition of human immunodeficiency virus syncytium formation and virus replication by castanospermine. Proc Natl Acad Sci U S A. 1987 Nov; 84(22):8120-4. PMID: 2825177; PMCID: PMC299490.
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    505. Drucker D, Rosen C. Excess circulating androgen levels in the pathogenesis of acne. J Invest Dermatol. 1984 Jan; 82(1):112. PMID: 6228609.
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