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Douglas M. Jefferson

TitleAssociate Professor
InstitutionTufts University School of Medicine
DepartmentIntegrative Physiology and Pathobiology
AddressIntegrative Physiology and Pathobiology
Tufts University School of Medicine
136 Harrison Avenue
Boston MA 02111-1800
Phone(617) 636-7965
Fax(617) 636-4233
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Grubman SA, Shin J, Phelan PJ, Gong A, Can H, Dilworth R, Kini SK, Gagnon D, Archambault J, Meinke G, Bohm A, Jefferson DM, Bullock PA. Isolation of a monoclonal antibody that recognizes the origin binding domain of JCV, but not SV40, large T-antigen. Virology. 2016 Oct; 497:92-101. PMID: 27433780.
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    2. Schrumpf E, Tan C, Karlsen TH, Sponheim J, Björkström NK, Sundnes O, Alfsnes K, Kaser A, Jefferson DM, Ueno Y, Eide TJ, Haraldsen G, Zeissig S, Exley MA, Blumberg RS, Melum E. The biliary epithelium presents antigens to and activates natural killer T cells. Hepatology. 2015 Oct; 62(4):1249-59. PMID: 25855031.
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    3. Onori P, Mancinelli R, Franchitto A, Carpino G, Renzi A, Brozzetti S, Venter J, Francis H, Glaser S, Jefferson DM, Alpini G, Gaudio E. Role of follicle-stimulating hormone on biliary cyst growth in autosomal dominant polycystic kidney disease. Liver Int. 2013 Jul; 33(6):914-25. PMID: 23617956; NIHMSID: NIHMS460150.
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    4. Müller T, Beutler C, Picó AH, Otten M, Dürr A, Al-Abadi H, Guckelberger O, Meyer Zum Büschenfelde D, Jöhrens K, Volkmann M, Lankisch T, Voigtländer T, Anders M, Shibolet O, Jefferson DM, Podolsky DK, Fischer A, Veltzke-Schlieker W, Adler A, Baumgart DC, Sturm A, Wiedenmann B, Schott E, Berg T. Increased T-helper 2 cytokines in bile from patients with IgG4-related cholangitis disrupt the tight junction-associated biliary epithelial cell barrier. Gastroenterology. 2013 May; 144(5):1116-28. PMID: 23391819.
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    5. Hohenester S, Wenniger LM, Paulusma CC, van Vliet SJ, Jefferson DM, Elferink RP, Beuers U. A biliary HCO3- umbrella constitutes a protective mechanism against bile acid-induced injury in human cholangiocytes. Hepatology. 2012 Jan; 55(1):173-83. PMID: 21932391.
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    6. Kowalczyk C, Dunkel N, Willen L, Casal ML, Mauldin EA, Gaide O, Tardivel A, Badic G, Etter AL, Favre M, Jefferson DM, Headon DJ, Demotz S, Schneider P. Molecular and therapeutic characterization of anti-ectodysplasin A receptor (EDAR) agonist monoclonal antibodies. J Biol Chem. 2011 Sep 2; 286(35):30769-79. PMID: 21730053; PMCID: PMC3162438.
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    7. Hohenester S, Maillette de Buy Wenniger L, Jefferson DM, Oude Elferink RP, Beuers U. Biliary bicarbonate secretion constitutes a protective mechanism against bile acid-induced injury in man. Dig Dis. 2011; 29(1):62-5. PMID: 21691107.
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    8. Gutierrez JA, Klepper AL, Garber J, Walewski JL, Bateman K, Khaitova V, Syder A, Tscherne DM, Gauthier A, Jefferson D, Rice CM, Schiano TD, Branch AD. Cross-genotypic polyclonal anti-HCV antibodies from human ascitic fluid. J Virol Methods. 2011 Jan; 171(1):169-75. PMID: 21034775; NIHMSID: NIHMS254683.
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    9. Keller PJ, Lin AF, Arendt LM, Klebba I, Jones AD, Rudnick JA, DiMeo TA, Gilmore H, Jefferson DM, Graham RA, Naber SP, Schnitt S, Kuperwasser C. Mapping the cellular and molecular heterogeneity of normal and malignant breast tissues and cultured cell lines. Breast Cancer Res. 2010; 12(5):R87. PMID: 20964822.
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    10. Chen B, Jefferson DM, Cho WK. Characterization of volume-activated chloride currents in regulatory volume decrease of human cholangiocyte. J Membr Biol. 2010 May; 235(1):17-26. PMID: 20411247.
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    11. Kido O, Fukushima K, Ueno Y, Inoue J, Jefferson DM, Shimosegawa T. Compensatory role of inducible annexin A2 for impaired biliary epithelial anion-exchange activity of inflammatory cholangiopathy. Lab Invest. 2009 Dec; 89(12):1374-86. PMID: 19823170.
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    12. Alvaro D, Onori P, Alpini G, Franchitto A, Jefferson DM, Torrice A, Cardinale V, Stefanelli F, Mancino MG, Strazzabosco M, Angelico M, Attili A, Gaudio E. Morphological and functional features of hepatic cyst epithelium in autosomal dominant polycystic kidney disease. Am J Pathol. 2008 Feb; 172(2):321-32. PMID: 18202196; PMCID: PMC2312356.
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    13. Tamai K, Fukushima K, Ueno Y, Moritoki Y, Yamagiwa Y, Kanno N, Jefferson DM, Shimosegawa T. Differential expressions of aquaporin proteins in human cholestatic liver diseases. Hepatol Res. 2006 Feb; 34(2):99-103. PMID: 16406793.
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    14. Husson H, Manavalan P, Akmaev VR, Russo RJ, Cook B, Richards B, Barberio D, Liu D, Cao X, Landes GM, Wang CJ, Roberts BL, Klinger KW, Grubman SA, Jefferson DM, Ibraghimov-Beskrovnaya O. New insights into ADPKD molecular pathways using combination of SAGE and microarray technologies. Genomics. 2004 Sep; 84(3):497-510. PMID: 15498457.
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    15. Abraham EH, Sterling KM, Kim RJ, Salikhova AY, Huffman HB, Crockett MA, Johnston N, Parker HW, Boyle WE, Hartov A, Demidenko E, Efird J, Kahn J, Grubman SA, Jefferson DM, Robson SC, Thakar JH, Lorico A, Rappa G, Sartorelli AC, Okunieff P. Erythrocyte membrane ATP binding cassette (ABC) proteins: MRP1 and CFTR as well as CD39 (ecto-apyrase) involved in RBC ATP transport and elevated blood plasma ATP of cystic fibrosis. Blood Cells Mol Dis. 2001 Jan-Feb; 27(1):165-80. PMID: 11358378.
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    16. Hreha G, Jefferson DM, Yu CH, Grubman SA, Alsabeh R, Geller SA, Vierling JM. Immortalized intrahepatic mouse biliary epithelial cells: immunologic characterization and immunogenicity. Hepatology. 1999 Aug; 30(2):358-71. PMID: 10421641.
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    17. Chen XM, Levine SA, Tietz P, Krueger E, McNiven MA, Jefferson DM, Mahle M, LaRusso NF. Cryptosporidium parvum is cytopathic for cultured human biliary epithelia via an apoptotic mechanism. Hepatology. 1998 Oct; 28(4):906-13. PMID: 9755224.
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    18. Jiang C, Fang SL, Xiao YF, O'Connor SP, Nadler SG, Lee DW, Jefferson DM, Kaplan JM, Smith AE, Cheng SH. Partial restoration of cAMP-stimulated CFTR chloride channel activity in DeltaF508 cells by deoxyspergualin. Am J Physiol. 1998 Jul; 275(1 Pt 1):C171-8. PMID: 9688848.
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    19. Cao Z, Jefferson DM, Panjwani N. Role of carbohydrate-mediated adherence in cytopathogenic mechanisms of Acanthamoeba. J Biol Chem. 1998 Jun 19; 273(25):15838-45. PMID: 9624184.
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    20. Soltoff SP, Grubman SA, Jefferson DM. Development of salivary gland cell lines for studies of signaling and physiology. Ann N Y Acad Sci. 1998 Apr 15; 842:100-7. PMID: 9599299.
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    21. St Pierre MV, Schlenker T, Dufour JF, Jefferson DM, Fitz JG, Arias IM. Stimulation of cyclic guanosine monophosphate production by natriuretic peptide in human biliary cells. Gastroenterology. 1998 Apr; 114(4):782-90. PMID: 9516399.
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    22. Bhaskar KR, Turner BS, Grubman SA, Jefferson DM, LaMont JT. Dysregulation of proteoglycan production by intrahepatic biliary epithelial cells bearing defective (delta-f508) cystic fibrosis transmembrane conductance regulator. Hepatology. 1998 Jan; 27(1):7-14. PMID: 9425910.
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    23. Perrone RD, Grubman SA, Murray SL, Lee DW, Alper SL, Jefferson DM. Autosomal dominant polycystic kidney disease decreases anion exchanger activity. Am J Physiol. 1997 May; 272(5 Pt 1):C1748-56. PMID: 9176168.
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    24. Verdon R, Keusch GT, Tzipori S, Grubman SA, Jefferson DM, Ward HD. An in vitro model of infection of human biliary epithelial cells by Cryptosporidium parvum. J Infect Dis. 1997 May; 175(5):1268-72. PMID: 9129102.
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    25. Jiang C, O'Connor SP, Armentano D, Berthelette PB, Schiavi SC, Jefferson DM, Smith AE, Wadsworth SC, Cheng SH. Ability of adenovirus vectors containing different CFTR transcriptional cassettes to correct ion transport defects in CF cells. Am J Physiol. 1996 Oct; 271(4 Pt 1):L527-37. PMID: 8897899.
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    26. Abraham EH, Vos P, Kahn J, Grubman SA, Jefferson DM, Ding I, Okunieff P. Cystic fibrosis hetero- and homozygosity is associated with inhibition of breast cancer growth. Nat Med. 1996 May; 2(5):593-6. PMID: 8616723.
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    27. Perrone RD, Johns C, Grubman SA, Moy E, Lee DW, Alroy J, Sant GR, Jefferson DM. Immortalized human bladder cell line exhibits amiloride-sensitive sodium absorption. Am J Physiol. 1996 Jan; 270(1 Pt 2):F148-53. PMID: 8769833.
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    28. Murray SL, Grubman SA, Perrone RD, Rojkind M, Moy E, Lee DW, Jefferson DM. Matrix metalloproteinase activity in human intrahepatic biliary epithelial cell lines from patients with autosomal dominant polycystic kidney disease. Connect Tissue Res. 1996; 33(4):249-56. PMID: 8834442.
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    29. Perrone RD, Grubman SA, Rogers LC, Lee DW, Moy E, Murray SL, Torres VE, Jefferson DM. Continuous epithelial cell lines from ADPKD liver cysts exhibit characteristics of intrahepatic biliary epithelium. Am J Physiol. 1995 Sep; 269(3 Pt 1):G335-45. PMID: 7573443.
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    30. Mulberg AE, Resta LP, Wiedner EB, Altschuler SM, Jefferson DM, Broussard DL. Expression and localization of the cystic fibrosis transmembrane conductance regulator mRNA and its protein in rat brain. J Clin Invest. 1995 Jul; 96(1):646-52. PMID: 7542288; PMCID: PMC185240.
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    31. Wolkoff LI, Perrone RD, Grubman SA, Lee DW, Soltoff SP, Rogers LC, Beinborn M, Fang SL, Cheng SH, Jefferson DM. Purinoceptor P2U identification and function in human intrahepatic biliary epithelial cell lines. Cell Calcium. 1995 May; 17(5):375-83. PMID: 7553790.
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    32. Cheng SH, Fang SL, Zabner J, Marshall J, Piraino S, Schiavi SC, Jefferson DM, Welsh MJ, Smith AE. Functional activation of the cystic fibrosis trafficking mutant delta F508-CFTR by overexpression. Am J Physiol. 1995 Apr; 268(4 Pt 1):L615-24. PMID: 7733303.
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    33. Bachinsky DR, Sabolic I, Emmanouel DS, Jefferson DM, Carone FA, Brown D, Perrone RD. Water channel expression in human ADPKD kidneys. Am J Physiol. 1995 Mar; 268(3 Pt 2):F398. PMID: 7535000.
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    34. Mulberg AE, Wiedner EB, Bao X, Marshall J, Jefferson DM, Altschuler SM. Cystic fibrosis transmembrane conductance regulator protein expression in brain. Neuroreport. 1994 Aug 15; 5(13):1684-8. PMID: 7529593.
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    35. da Silva JC, Shi XJ, Johns CA, Jefferson DM, Grubman SA, Madias NE, Perrone RD. Experimental renal failure in the rat modulates cardiac Na,K-ATPase alpha 2 mRNA but not protein. J Am Soc Nephrol. 1994 Jul; 5(1):27-35. PMID: 7948781.
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    36. Johnston DE, Jefferson DM. Characterization of a serum factor that decreases albumin mRNA in cultured hepatocytes. In Vitro Cell Dev Biol Anim. 1994 Jul; 30A(7):464-70. PMID: 7524978.
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    37. Grubman SA, Perrone RD, Lee DW, Murray SL, Rogers LC, Wolkoff LI, Mulberg AE, Cherington V, Jefferson DM. Regulation of intracellular pH by immortalized human intrahepatic biliary epithelial cell lines. Am J Physiol. 1994 Jun; 266(6 Pt 1):G1060-70. PMID: 8023938.
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    38. Ruef C, Jefferson DM, Schlegel-Haueter SE, Suter S. Regulation of cytokine secretion by cystic fibrosis airway epithelial cells. Eur Respir J. 1993 Nov; 6(10):1429-36. PMID: 8112434.
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    39. Johnston DE, Peterson MB, Mion F, Berninger RW, Jefferson DM. Synthesis and degradation of eicosanoids in primary rat hepatocyte cultures. Prostaglandins Leukot Essent Fatty Acids. 1991 Jun; 43(2):119-32. PMID: 1909439.
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    40. Jefferson DM, Valentich JD, Marini FC, Grubman SA, Iannuzzi MC, Dorkin HL, Li M, Klinger KW, Welsh MJ. Expression of normal and cystic fibrosis phenotypes by continuous airway epithelial cell lines. Am J Physiol. 1990 Dec; 259(6 Pt 1):L496-505. PMID: 1701980.
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    41. Rich DP, Anderson MP, Gregory RJ, Cheng SH, Paul S, Jefferson DM, McCann JD, Klinger KW, Smith AE, Welsh MJ. Expression of cystic fibrosis transmembrane conductance regulator corrects defective chloride channel regulation in cystic fibrosis airway epithelial cells. Nature. 1990 Sep 27; 347(6291):358-63. PMID: 1699126.
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    42. Wilson JM, Johnston DE, Jefferson DM, Mulligan RC. Correction of the genetic defect in hepatocytes from the Watanabe heritable hyperlipidemic rabbit. Proc Natl Acad Sci U S A. 1988 Jun; 85(12):4421-5. PMID: 2454468; PMCID: PMC280441.
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    43. Wilson JM, Jefferson DM, Chowdhury JR, Novikoff PM, Johnston DE, Mulligan RC. Retrovirus-mediated transduction of adult hepatocytes. Proc Natl Acad Sci U S A. 1988 May; 85(9):3014-8. PMID: 2834728; PMCID: PMC280133.
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    44. Weiner FR, Czaja MJ, Jefferson DM, Giambrone MA, Tur-Kaspa R, Reid LM, Zern MA. The effects of dexamethasone on in vitro collagen gene expression. J Biol Chem. 1987 May 25; 262(15):6955-8. PMID: 3584102.
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    45. Fujita M, Spray DC, Choi H, Saez J, Jefferson DM, Hertzberg E, Rosenberg LC, Reid LM. Extracellular matrix regulation of cell-cell communication and tissue-specific gene expression in primary liver cultures. Prog Clin Biol Res. 1986; 226:333-60. PMID: 3543962.
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    46. Jefferson DM, Reid LM, Giambrone MA, Shafritz DA, Zern MA. Effects of dexamethasone on albumin and collagen gene expression in primary cultures of adult rat hepatocytes. Hepatology. 1985 Jan-Feb; 5(1):14-20. PMID: 3967856.
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    47. Jefferson DM, Clayton DF, Darnell JE, Reid LM. Posttranscriptional modulation of gene expression in cultured rat hepatocytes. Mol Cell Biol. 1984 Sep; 4(9):1929-34. PMID: 6333585; PMCID: PMC369002.
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    48. Reid LM, Jefferson DM. Culturing hepatocytes and other differentiated cells. Hepatology. 1984 May-Jun; 4(3):548-59. PMID: 6373552.
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    49. Enat R, Jefferson DM, Ruiz-Opazo N, Gatmaitan Z, Leinwand LA, Reid LM. Hepatocyte proliferation in vitro: its dependence on the use of serum-free hormonally defined medium and substrata of extracellular matrix. Proc Natl Acad Sci U S A. 1984 Mar; 81(5):1411-5. PMID: 6584889; PMCID: PMC344845.
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    50. Gatmaitan Z, Jefferson DM, Ruiz-Opazo N, Biempica L, Arias IM, Dudas G, Leinwand LA, Reid LM. Regulation of growth and differentiation of a rat hepatoma cell line by the synergistic interactions of hormones and collagenous substrata. J Cell Biol. 1983 Oct; 97(4):1179-90. PMID: 6137487; PMCID: PMC2112632.
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    This website was supported by the National Center for Research Resources Award Number UL1RR025752 and the National Center for Advancing Translational Sciences, National Institutes of Health, Award Numbers UL1TR000073 and UL1TR001064. The content is solely the responsibility of the authors and does not necessarily represent the official views of the NIH.

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