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Janis Lem

TitleResearch Associate Professor
InstitutionTufts Medical Center
DepartmentMedicine
AddressMolecular Cardiology Research Institute
Tufts Medical Center
800 Washington Street, Box 5045
Boston MA 02111-1800
Phone(617) 636-5045
Fax(617) 636-8362
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Cowan CS, Abd-El-Barr M, van der Heijden M, Lo EM, Paul D, Bramblett DE, Lem J, Simons DL, Wu SM. Connexin 36 and rod bipolar cell independent rod pathways drive retinal ganglion cells and optokinetic reflexes. Vision Res. 2016 Feb; 119:99-109. PMID: 26718442.
      View in: PubMed
    2. Myers RB, Rwayitare K, Richey L, Lem J, Castellot JJ. CCN5 Expression in mammals. III. Early embryonic mouse development. J Cell Commun Signal. 2012 Dec; 6(4):217-23. PMID: 22926930; PMCID: PMC3497895.
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    3. Makino CL, Wen XH, Michaud NA, Covington HI, DiBenedetto E, Hamm HE, Lem J, Caruso G. Rhodopsin expression level affects rod outer segment morphology and photoresponse kinetics. PLoS One. 2012; 7(5):e37832. PMID: 22662234; PMCID: PMC3360601.
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    4. Maeda A, Okano K, Park PS, Lem J, Crouch RK, Maeda T, Palczewski K. Palmitoylation stabilizes unliganded rod opsin. Proc Natl Acad Sci U S A. 2010 May 4; 107(18):8428-33. PMID: 20404157; PMCID: PMC2889565.
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    5. Pang JJ, Gao F, Lem J, Bramblett DE, Paul DL, Wu SM. Direct rod input to cone BCs and direct cone input to rod BCs challenge the traditional view of mammalian BC circuitry. Proc Natl Acad Sci U S A. 2010 Jan 5; 107(1):395-400. PMID: 20018684; PMCID: PMC2806755.
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    6. Malanson KM, Lem J. Rhodopsin-mediated retinitis pigmentosa. Prog Mol Biol Transl Sci. 2009; 88:1-31. PMID: 20374723.
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    7. Abd-El-Barr MM, Pennesi ME, Saszik SM, Barrow AJ, Lem J, Bramblett DE, Paul DL, Frishman LJ, Wu SM. Genetic dissection of rod and cone pathways in the dark-adapted mouse retina. J Neurophysiol. 2009 Sep; 102(3):1945-55. PMID: 19587322; PMCID: PMC2746771.
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    8. Park PS, Sapra KT, Jastrzebska B, Maeda T, Maeda A, Pulawski W, Kono M, Lem J, Crouch RK, Filipek S, Müller DJ, Palczewski K. Modulation of molecular interactions and function by rhodopsin palmitylation. Biochemistry. 2009 May 26; 48(20):4294-304. PMID: 19348429; NIHMSID: NIHMS109237.
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    9. Wen XH, Shen L, Brush RS, Michaud N, Al-Ubaidi MR, Gurevich VV, Hamm HE, Lem J, Dibenedetto E, Anderson RE, Makino CL. Overexpression of rhodopsin alters the structure and photoresponse of rod photoreceptors. Biophys J. 2009 Feb; 96(3):939-50. PMID: 19186132; PMCID: PMC2716671.
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    10. Brill E, Malanson KM, Radu RA, Boukharov NV, Wang Z, Chung HY, Lloyd MB, Bok D, Travis GH, Obin M, Lem J. A novel form of transducin-dependent retinal degeneration: accelerated retinal degeneration in the absence of rod transducin. Invest Ophthalmol Vis Sci. 2007 Dec; 48(12):5445-53. PMID: 18055791; NIHMSID: NIHMS39254.
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    11. Rosenzweig DH, Nair KS, Wei J, Wang Q, Garwin G, Saari JC, Chen CK, Smrcka AV, Swaroop A, Lem J, Hurley JB, Slepak VZ. Subunit dissociation and diffusion determine the subcellular localization of rod and cone transducins. J Neurosci. 2007 May 16; 27(20):5484-94. PMID: 17507570; NIHMSID: NIHMS92826.
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    12. Rajala A, Anderson RE, Ma JX, Lem J, Al-Ubaidi MR, Rajala RV. G-protein-coupled receptor rhodopsin regulates the phosphorylation of retinal insulin receptor. J Biol Chem. 2007 Mar 30; 282(13):9865-73. PMID: 17272282.
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    13. Srinivasan VJ, Ko TH, Wojtkowski M, Carvalho M, Clermont A, Bursell SE, Song QH, Lem J, Duker JS, Schuman JS, Fujimoto JG. Noninvasive volumetric imaging and morphometry of the rodent retina with high-speed, ultrahigh-resolution optical coherence tomography. Invest Ophthalmol Vis Sci. 2006 Dec; 47(12):5522-8. PMID: 17122144; NIHMSID: NIHMS24613.
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    14. Bemelmans AP, Kostic C, Crippa SV, Hauswirth WW, Lem J, Munier FL, Seeliger MW, Wenzel A, Arsenijevic Y. Lentiviral gene transfer of RPE65 rescues survival and function of cones in a mouse model of Leber congenital amaurosis. PLoS Med. 2006 Oct; 3(10):e347. PMID: 17032058; PMCID: PMC1592340.
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    15. Moussaif M, Rubin WW, Kerov V, Reh R, Chen D, Lem J, Chen CK, Hurley JB, Burns ME, Artemyev NO. Phototransduction in a transgenic mouse model of Nougaret night blindness. J Neurosci. 2006 Jun 21; 26(25):6863-72. PMID: 16793893.
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    16. Nikonov SS, Kholodenko R, Lem J, Pugh EN. Physiological features of the S- and M-cone photoreceptors of wild-type mice from single-cell recordings. J Gen Physiol. 2006 Apr; 127(4):359-74. PMID: 16567464; PMCID: PMC2151510.
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    17. Bemelmans AP, Kostic C, Hornfeld D, Jaquet M, Crippa SV, Hauswirth WW, Lem J, Wang Z, Schorderet DE, Munier FL, Wenzel A, Arsenijevic Y. Lentiviral vectors containing a retinal pigment epithelium specific promoter for leber congenital amaurosis gene therapy. Lentiviral gene therapy for LCA. Adv Exp Med Biol. 2006; 572:247-53. PMID: 17249581.
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    18. Maeda T, Lem J, Palczewski K, Haeseleer F. A critical role of CaBP4 in the cone synapse. Invest Ophthalmol Vis Sci. 2005 Nov; 46(11):4320-7. PMID: 16249514; NIHMSID: NIHMS6476.
      View in: PubMed
    19. Wang Z, Wen XH, Ablonczy Z, Crouch RK, Makino CL, Lem J. Enhanced shutoff of phototransduction in transgenic mice expressing palmitoylation-deficient rhodopsin. J Biol Chem. 2005 Jul 1; 280(26):24293-300. PMID: 15851469; NIHMSID: NIHMS39249.
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    20. Naash MI, Wu TH, Chakraborty D, Fliesler SJ, Ding XQ, Nour M, Peachey NS, Lem J, Qtaishat N, Al-Ubaidi MR, Ripps H. Retinal abnormalities associated with the G90D mutation in opsin. J Comp Neurol. 2004 Oct 11; 478(2):149-63. PMID: 15349976.
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    21. He W, Yasumatsu K, Varadarajan V, Yamada A, Lem J, Ninomiya Y, Margolskee RF, Damak S. Umami taste responses are mediated by alpha-transducin and alpha-gustducin. J Neurosci. 2004 Sep 1; 24(35):7674-80. PMID: 15342734.
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    22. Woodruff ML, Lem J, Fain GL. Early receptor current of wild-type and transducin knockout mice: photosensitivity and light-induced Ca2+ release. J Physiol. 2004 Jun 15; 557(Pt 3):821-8. PMID: 15073279; PMCID: PMC1665159.
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    23. Lem J, Fain GL. Constitutive opsin signaling: night blindness or retinal degeneration? Trends Mol Med. 2004 Apr; 10(4):150-7. PMID: 15059605.
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    24. Danciger M, Lyon J, Worrill D, Hoffman S, Lem J, Reme CE, Wenzel A, Grimm C. New retinal light damage QTL in mice with the light-sensitive RPE65 LEU variant. Mamm Genome. 2004 Apr; 15(4):277-83. PMID: 15112105.
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    25. Martemyanov KA, Lishko PV, Calero N, Keresztes G, Sokolov M, Strissel KJ, Leskov IB, Hopp JA, Kolesnikov AV, Chen CK, Lem J, Heller S, Burns ME, Arshavsky VY. The DEP domain determines subcellular targeting of the GTPase activating protein RGS9 in vivo. J Neurosci. 2003 Nov 12; 23(32):10175-81. PMID: 14614075.
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    26. Woodruff ML, Wang Z, Chung HY, Redmond TM, Fain GL, Lem J. Spontaneous activity of opsin apoprotein is a cause of Leber congenital amaurosis. Nat Genet. 2003 Oct; 35(2):158-64. PMID: 14517541.
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    27. Makino CL, Wen XH, Lem J. Piecing together the timetable for visual transduction with transgenic animals. Curr Opin Neurobiol. 2003 Aug; 13(4):404-12. PMID: 12965286.
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    28. Mendez A, Lem J, Simon M, Chen J. Light-dependent translocation of arrestin in the absence of rhodopsin phosphorylation and transducin signaling. J Neurosci. 2003 Apr 15; 23(8):3124-9. PMID: 12716919.
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    29. Brill E, Patnala S, Lem J, Obin M. Bright light induces retinal degeneration by a transducin-independent mechanism. Adv Exp Med Biol. 2003; 533:213-9. PMID: 15180267.
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    30. Hao W, Wenzel A, Obin MS, Chen CK, Brill E, Krasnoperova NV, Eversole-Cire P, Kleyner Y, Taylor A, Simon MI, Grimm C, Remé CE, Lem J. Evidence for two apoptotic pathways in light-induced retinal degeneration. Nat Genet. 2002 Oct; 32(2):254-60. PMID: 12219089.
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    31. Lem J, Krasnoperova NV, Calvert PD, Kosaras B, Cameron DA, Nicolò M, Makino CL, Sidman RL. Morphological, physiological, and biochemical changes in rhodopsin knockout mice. Proc Natl Acad Sci U S A. 1999 Jan 19; 96(2):736-41. PMID: 9892703; PMCID: PMC15206.
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      View in: PubMed Central
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    This website was supported by the National Center for Research Resources Award Number UL1RR025752 and the National Center for Advancing Translational Sciences, National Institutes of Health, Award Numbers UL1TR000073 and UL1TR001064. The content is solely the responsibility of the authors and does not necessarily represent the official views of the NIH.

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